Modulation of Inflammatory Responses by Wnt/β-catenin Signaling in Dendritic cells: A Novel Immunotherapy target for auto-immunity and Cancer

• Main Authors: Amol Suryawanshi, Raghu K Tadagavadi, Daniel Swafford, Santhakumar Manicassamy
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2016-10-01
• Series: Frontiers in Immunology
• Subjects: Autoimmune Diseases; Dendritic Cells; Immunotherapy; Wnt; chronic inflammation; anti-tumor immunity
• Online Access: http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00460/full

The Wnt/β-catenin pathway is an evolutionarily conserved signaling pathway critical for several biological processes. An aberrant Wnt/β-catenin signaling is linked to several human diseases. Emerging studies have highlighted the regulatory role of the Wnt/β-catenin signaling pathway in normal physiological processes of parenchymal and hematopoietic cells. Recent studies have shown that the activation of Wnt/β-catenin pathway in dendritic cells (DCs) play a critical role in mucosal tolerance and suppression of chronic auto-immune pathologies. Alternatively, tumors activate Wnt/β-catenin pathway in DCs to induce immune tolerance and thereby evade anti-tumor immunity through suppression of effector T cell responses and promotion of regulatory T cell responses. Here, we review our work and current understanding of how Wnt/β-catenin signaling in DCs shapes the immune response in cancer and autoimmunity and discuss how Wnt/β -catenin pathway can be targeted for successful therapeutic interventions in various human diseases.