Curcumin’s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway
Curcumin (CUR), a promising naturally occurring dietary compound, is commonly recognized as the potential anti-inflammatory agent. While the application of CUR was hampered by its low stability and poor systemic bioavailability, it has been suggested that the biological activities of CUR are intimat...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2018-10-01
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Series: | Frontiers in Pharmacology |
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Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.01181/full |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhen-Biao Zhang Zhen-Biao Zhang Dan-Dan Luo Jian-Hui Xie Yan-Fang Xian Zheng-Quan Lai Zheng-Quan Lai Yu-Hong Liu Wei-Hai Liu Jian-Nan Chen Xiao-Ping Lai Xiao-Ping Lai Zhi-Xiu Lin Zhi-Xiu Lin Zi-Ren Su Zi-Ren Su |
spellingShingle |
Zhen-Biao Zhang Zhen-Biao Zhang Dan-Dan Luo Jian-Hui Xie Yan-Fang Xian Zheng-Quan Lai Zheng-Quan Lai Yu-Hong Liu Wei-Hai Liu Jian-Nan Chen Xiao-Ping Lai Xiao-Ping Lai Zhi-Xiu Lin Zhi-Xiu Lin Zi-Ren Su Zi-Ren Su Curcumin’s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway Frontiers in Pharmacology tetrahydrocurcumin octahydrocucumin curcumin inflammation COX-2 TAK1-NF-κB pathway |
author_facet |
Zhen-Biao Zhang Zhen-Biao Zhang Dan-Dan Luo Jian-Hui Xie Yan-Fang Xian Zheng-Quan Lai Zheng-Quan Lai Yu-Hong Liu Wei-Hai Liu Jian-Nan Chen Xiao-Ping Lai Xiao-Ping Lai Zhi-Xiu Lin Zhi-Xiu Lin Zi-Ren Su Zi-Ren Su |
author_sort |
Zhen-Biao Zhang |
title |
Curcumin’s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway |
title_short |
Curcumin’s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway |
title_full |
Curcumin’s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway |
title_fullStr |
Curcumin’s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway |
title_full_unstemmed |
Curcumin’s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway |
title_sort |
curcumin’s metabolites, tetrahydrocurcumin and octahydrocurcumin, possess superior anti-inflammatory effects in vivo through suppression of tak1-nf-κb pathway |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2018-10-01 |
description |
Curcumin (CUR), a promising naturally occurring dietary compound, is commonly recognized as the potential anti-inflammatory agent. While the application of CUR was hampered by its low stability and poor systemic bioavailability, it has been suggested that the biological activities of CUR are intimately related to its metabolites. In the current investigation, we aimed to comparatively explore the anti-inflammatory effects of tetrahydrocurcumin (THC), octahydrocurcumin (OHC), and CUR, and to elucidate the underlying action mechanisms on experimental mice models of acute inflammation, i.e., xylene-induced ear edema, acetic acid-induced vascular permeability, and carrageenan-induced paw edema. The results showed that THC and OHC exerted significant and dose-dependent inhibitions on the formation of ear edema induced by xylene and paw edema provoked by carrageenan and inhibited the Evans blue dye leakage in peritoneal cavity elicited by acetic acid. Moreover, THC and OHC treatments were more effective than CUR in selectively inhibiting the expression of cyclooxygenase 2 (COX-2) and suppressing nuclear factor-κB (NF-κB) pathways via transforming growth factor β activated kinase-1 (TAK1) inactivation in the carrageenan-induced mouse paw edema model. |
topic |
tetrahydrocurcumin octahydrocucumin curcumin inflammation COX-2 TAK1-NF-κB pathway |
url |
https://www.frontiersin.org/article/10.3389/fphar.2018.01181/full |
work_keys_str_mv |
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doaj-f58a04ff6fb6422e90869e3dca5382542020-11-24T21:06:53ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-10-01910.3389/fphar.2018.01181407895Curcumin’s Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB PathwayZhen-Biao Zhang0Zhen-Biao Zhang1Dan-Dan Luo2Jian-Hui Xie3Yan-Fang Xian4Zheng-Quan Lai5Zheng-Quan Lai6Yu-Hong Liu7Wei-Hai Liu8Jian-Nan Chen9Xiao-Ping Lai10Xiao-Ping Lai11Zhi-Xiu Lin12Zhi-Xiu Lin13Zi-Ren Su14Zi-Ren Su15Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, ChinaSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaGuangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, ChinaSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaDepartment of Pharmacy, Shenzhen University General Hospital, Shenzhen University, Shenzhen, ChinaGuangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, ChinaGuangdong Food and Drug Vocational College, Guangzhou, ChinaHigher Education Institute and Development Research of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, ChinaGuangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Dongguan, ChinaGuangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, ChinaSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaGuangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Dongguan, ChinaCurcumin (CUR), a promising naturally occurring dietary compound, is commonly recognized as the potential anti-inflammatory agent. While the application of CUR was hampered by its low stability and poor systemic bioavailability, it has been suggested that the biological activities of CUR are intimately related to its metabolites. In the current investigation, we aimed to comparatively explore the anti-inflammatory effects of tetrahydrocurcumin (THC), octahydrocurcumin (OHC), and CUR, and to elucidate the underlying action mechanisms on experimental mice models of acute inflammation, i.e., xylene-induced ear edema, acetic acid-induced vascular permeability, and carrageenan-induced paw edema. The results showed that THC and OHC exerted significant and dose-dependent inhibitions on the formation of ear edema induced by xylene and paw edema provoked by carrageenan and inhibited the Evans blue dye leakage in peritoneal cavity elicited by acetic acid. Moreover, THC and OHC treatments were more effective than CUR in selectively inhibiting the expression of cyclooxygenase 2 (COX-2) and suppressing nuclear factor-κB (NF-κB) pathways via transforming growth factor β activated kinase-1 (TAK1) inactivation in the carrageenan-induced mouse paw edema model.https://www.frontiersin.org/article/10.3389/fphar.2018.01181/fulltetrahydrocurcuminoctahydrocucumincurcumininflammationCOX-2TAK1-NF-κB pathway |