The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis

In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this...

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Main Authors:	Shang Li, Wei Chen, Hong Lu, Xiaofeng Hu, Yingzhi Xu, Jing Wang
Format:	Article
Language:	English
Published:	MDPI AG 2012-02-01
Series:	International Journal of Molecular Sciences
Subjects:	Toll-like receptor 4 Cytokine cytometric bead array technology aqueous humor Anterior Uveitis
Online Access:	http://www.mdpi.com/1422-0067/13/2/2110/

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spelling	doaj-f5979313dcf748ce840ccab96ef7880e2020-11-24T23:56:30ZengMDPI AGInternational Journal of Molecular Sciences1422-00672012-02-011322110211810.3390/ijms13022110The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced UveitisShang LiWei ChenHong LuXiaofeng HuYingzhi XuJing WangIn our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with the aim of exploring the role of different cytokines in the lipopolysaccharide (LPS) and TLR4-mediated signal transduction in the development of AAU.http://www.mdpi.com/1422-0067/13/2/2110/Toll-like receptor 4Cytokinecytometric bead array technologyaqueous humorAnterior Uveitis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shang Li Wei Chen Hong Lu Xiaofeng Hu Yingzhi Xu Jing Wang
spellingShingle	Shang Li Wei Chen Hong Lu Xiaofeng Hu Yingzhi Xu Jing Wang The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis International Journal of Molecular Sciences Toll-like receptor 4 Cytokine cytometric bead array technology aqueous humor Anterior Uveitis
author_facet	Shang Li Wei Chen Hong Lu Xiaofeng Hu Yingzhi Xu Jing Wang
author_sort	Shang Li
title	The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis
title_short	The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis
title_full	The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis
title_fullStr	The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis
title_full_unstemmed	The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis
title_sort	effect of toll-like receptor 4 in the aqueous humor of endotoxin-induced uveitis
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2012-02-01
description	In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with the aim of exploring the role of different cytokines in the lipopolysaccharide (LPS) and TLR4-mediated signal transduction in the development of AAU.
topic	Toll-like receptor 4 Cytokine cytometric bead array technology aqueous humor Anterior Uveitis
url	http://www.mdpi.com/1422-0067/13/2/2110/
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The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis

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