The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis
In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this...
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doaj-f5979313dcf748ce840ccab96ef7880e2020-11-24T23:56:30ZengMDPI AGInternational Journal of Molecular Sciences1422-00672012-02-011322110211810.3390/ijms13022110The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced UveitisShang LiWei ChenHong LuXiaofeng HuYingzhi XuJing WangIn our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with the aim of exploring the role of different cytokines in the lipopolysaccharide (LPS) and TLR4-mediated signal transduction in the development of AAU.http://www.mdpi.com/1422-0067/13/2/2110/Toll-like receptor 4Cytokinecytometric bead array technologyaqueous humorAnterior Uveitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shang Li Wei Chen Hong Lu Xiaofeng Hu Yingzhi Xu Jing Wang |
spellingShingle |
Shang Li Wei Chen Hong Lu Xiaofeng Hu Yingzhi Xu Jing Wang The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis International Journal of Molecular Sciences Toll-like receptor 4 Cytokine cytometric bead array technology aqueous humor Anterior Uveitis |
author_facet |
Shang Li Wei Chen Hong Lu Xiaofeng Hu Yingzhi Xu Jing Wang |
author_sort |
Shang Li |
title |
The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis |
title_short |
The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis |
title_full |
The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis |
title_fullStr |
The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis |
title_full_unstemmed |
The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis |
title_sort |
effect of toll-like receptor 4 in the aqueous humor of endotoxin-induced uveitis |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2012-02-01 |
description |
In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with the aim of exploring the role of different cytokines in the lipopolysaccharide (LPS) and TLR4-mediated signal transduction in the development of AAU. |
topic |
Toll-like receptor 4 Cytokine cytometric bead array technology aqueous humor Anterior Uveitis |
url |
http://www.mdpi.com/1422-0067/13/2/2110/ |
work_keys_str_mv |
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