Transcriptome analysis of proximal tubular cells (HK-2) exposed to urines of type 1 diabetes patients at risk of early progressive renal function decline.

Transcriptome analysis of proximal tubular cells (HK-2) exposed to urines of type 1 diabetes patients at risk of early progressive renal function decline.

<h4>Background</h4>In patients with Type 1 Diabetes (T1D) who develop microalbuminuria, progressive decline in glomerular filtration rate (GFR) may be initiated by leakage into the urine of toxic proteins (txUPs). This study tested this hypothesis.<h4>Methods</h4>After archiv...

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Main Authors: Krzysztof Wanic, Bozena Krolewski, Wenjun Ju, Grzegorz Placha, Monika A Niewczas, William Walker, James H Warram, Matthias Kretzler, Andrzej S Krolewski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23505438/pdf/?tool=EBI

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