DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty

DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty

Intravenous illicit drug use (IDU) and hepatitis C infection (HCV) often occur among HIV-infected individuals. Here, the authors report an epigenome-wide association analysis of IDU and HCV in HIV-infected individuals, finding that their associated methylation signatures inform HIV frailty.

Bibliographic Details
Main Authors: Xinyu Zhang, Ying Hu, Amy C Justice, Boyang Li, Zuoheng Wang, Hongyu Zhao, John H Krystal, Ke Xu
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02326-1
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spelling doaj-f59d61ac0ae14c6a946423923b595b792021-05-11T07:09:34ZengNature Publishing GroupNature Communications2041-17232017-12-018111110.1038/s41467-017-02326-1DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailtyXinyu Zhang0Ying Hu1Amy C Justice2Boyang Li3Zuoheng Wang4Hongyu Zhao5John H Krystal6Ke Xu7Department of Psychiatry, Yale School of MedicineNational Cancer Institute Center for Biomedical Information & Information TechnologyVA Connecticut Healthcare SystemDepartment of Biostatistics, Yale School of Public HealthDepartment of Biostatistics, Yale School of Public HealthDepartment of Biostatistics, Yale School of Public HealthDepartment of Psychiatry, Yale School of MedicineDepartment of Psychiatry, Yale School of MedicineIntravenous illicit drug use (IDU) and hepatitis C infection (HCV) often occur among HIV-infected individuals. Here, the authors report an epigenome-wide association analysis of IDU and HCV in HIV-infected individuals, finding that their associated methylation signatures inform HIV frailty.https://doi.org/10.1038/s41467-017-02326-1
collection DOAJ
language English
format Article
sources DOAJ
author Xinyu Zhang
Ying Hu
Amy C Justice
Boyang Li
Zuoheng Wang
Hongyu Zhao
John H Krystal
Ke Xu
spellingShingle Xinyu Zhang
Ying Hu
Amy C Justice
Boyang Li
Zuoheng Wang
Hongyu Zhao
John H Krystal
Ke Xu
DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty
Nature Communications
author_facet Xinyu Zhang
Ying Hu
Amy C Justice
Boyang Li
Zuoheng Wang
Hongyu Zhao
John H Krystal
Ke Xu
author_sort Xinyu Zhang
title DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty
title_short DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty
title_full DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty
title_fullStr DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty
title_full_unstemmed DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty
title_sort dna methylation signatures of illicit drug injection and hepatitis c are associated with hiv frailty
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-12-01
description Intravenous illicit drug use (IDU) and hepatitis C infection (HCV) often occur among HIV-infected individuals. Here, the authors report an epigenome-wide association analysis of IDU and HCV in HIV-infected individuals, finding that their associated methylation signatures inform HIV frailty.
url https://doi.org/10.1038/s41467-017-02326-1
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