Integrin αDβ2 (CD11d/CD18) Modulates Leukocyte Accumulation, Pathogen Clearance, and Pyroptosis in Experimental Salmonella Typhimurium Infection

Integrin αDβ2 (CD11d/CD18) Modulates Leukocyte Accumulation, Pathogen Clearance, and Pyroptosis in Experimental Salmonella Typhimurium Infection

β2 integrins are critical in host defense responses to invading pathogens and inflammation. Previously, we reported that genetic deficiency of integrin αDβ2 in mice altered outcomes in experimental systemic infections including accelerated mortality in animals infected with Salmonella enterica serov...

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Bibliographic Details
Main Authors: Danielle de Oliveira Nascimento, Adriana Vieira-de-Abreu, Angélica F. Arcanjo, Patricia Torres Bozza, Guy A. Zimmerman, Hugo Caire Castro-Faria-Neto
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
Salmonella enterica serovar Typhimurium pathogenesis
non-typhoidal Salmonella
myeloid leukocytes
macrophage
integrin
pyroptosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01128/full

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