A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents

A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents

Metal complexes play an essential role in pharmaceutical sciences for their multiple and important activities. Schiff bases are versatile pharmacophores able to form chelating complexes with several metals in different oxidation states. Complexes with Schiff bases are widely described in the literat...

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Main Authors: Alessia Catalano, Maria Stefania Sinicropi, Domenico Iacopetta, Jessica Ceramella, Annaluisa Mariconda, Camillo Rosano, Elisabetta Scali, Carmela Saturnino, Pasquale Longo
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Applied Sciences
Subjects:
schiff bases metal complexes
antitumor agents
apoptosis
antiproliferative activity
imines
Online Access:https://www.mdpi.com/2076-3417/11/13/6027
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spelling doaj-f5a4117f1283414db596638f9e5d28042021-07-15T15:30:23ZengMDPI AGApplied Sciences2076-34172021-06-01116027602710.3390/app11136027A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative AgentsAlessia Catalano0Maria Stefania Sinicropi1Domenico Iacopetta2Jessica Ceramella3Annaluisa Mariconda4Camillo Rosano5Elisabetta Scali6Carmela Saturnino7Pasquale Longo8Department of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, 70126 Bari, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, ItalyDepartment of Science, University of Basilicata, Viale Dell’Ateneo Lucano 10, 85100 Potenza, ItalyProteomics and Mass Spectrometry Unit IRCCS Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, ItalyDepartment of Health Sciences, Magna Graecia University, 88100 Catanzaro, ItalyDepartment of Science, University of Basilicata, Viale Dell’Ateneo Lucano 10, 85100 Potenza, ItalyDepartment of Biology and Chemistry, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, ItalyMetal complexes play an essential role in pharmaceutical sciences for their multiple and important activities. Schiff bases are versatile pharmacophores able to form chelating complexes with several metals in different oxidation states. Complexes with Schiff bases are widely described in the literature for their multiple actions and numerous advantages, such as low cost and easy synthesis. They show multiple biological activities, including antimicrobial, antioxidant, antimalarial, antinflammatory and antitumor. Schiff bases may also form complexes with lanthanides and actinides acting as catalysts (e.g., in various synthetic processes) and antitumor agents. This review intends to extend on our previous paper regarding Schiff bases as antitumorals, highlighting the importance, in the field of the anticancer agents, of these tools as ligands of metal complexes.https://www.mdpi.com/2076-3417/11/13/6027schiff bases metal complexesantitumor agentsapoptosisantiproliferative activityimines
collection DOAJ
language English
format Article
sources DOAJ
author Alessia Catalano
Maria Stefania Sinicropi
Domenico Iacopetta
Jessica Ceramella
Annaluisa Mariconda
Camillo Rosano
Elisabetta Scali
Carmela Saturnino
Pasquale Longo
spellingShingle Alessia Catalano
Maria Stefania Sinicropi
Domenico Iacopetta
Jessica Ceramella
Annaluisa Mariconda
Camillo Rosano
Elisabetta Scali
Carmela Saturnino
Pasquale Longo
A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents
Applied Sciences
schiff bases metal complexes
antitumor agents
apoptosis
antiproliferative activity
imines
author_facet Alessia Catalano
Maria Stefania Sinicropi
Domenico Iacopetta
Jessica Ceramella
Annaluisa Mariconda
Camillo Rosano
Elisabetta Scali
Carmela Saturnino
Pasquale Longo
author_sort Alessia Catalano
title A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents
title_short A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents
title_full A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents
title_fullStr A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents
title_full_unstemmed A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents
title_sort review on the advancements in the field of metal complexes with schiff bases as antiproliferative agents
publisher MDPI AG
series Applied Sciences
issn 2076-3417
publishDate 2021-06-01
description Metal complexes play an essential role in pharmaceutical sciences for their multiple and important activities. Schiff bases are versatile pharmacophores able to form chelating complexes with several metals in different oxidation states. Complexes with Schiff bases are widely described in the literature for their multiple actions and numerous advantages, such as low cost and easy synthesis. They show multiple biological activities, including antimicrobial, antioxidant, antimalarial, antinflammatory and antitumor. Schiff bases may also form complexes with lanthanides and actinides acting as catalysts (e.g., in various synthetic processes) and antitumor agents. This review intends to extend on our previous paper regarding Schiff bases as antitumorals, highlighting the importance, in the field of the anticancer agents, of these tools as ligands of metal complexes.
topic schiff bases metal complexes
antitumor agents
apoptosis
antiproliferative activity
imines
url https://www.mdpi.com/2076-3417/11/13/6027
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