Locoregional recurrence patterns in women with breast cancer who have not undergone post-mastectomy radiotherapy
Abstract Background To analyze the patterns of locoregional recurrence in breast cancer patients after mastectomy. Methods The retrospective study included 7073 women with breast cancer without post-mastectomy radiotherapy: 4604 (65.1%) had pT1–2 N0 disease (low risk); 2042 (28.9%), pT1–2 N1 (interm...
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BMC
2020-09-01
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Series: | Radiation Oncology |
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Online Access: | http://link.springer.com/article/10.1186/s13014-020-01637-w |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xuran Zhao Yu Tang Shulian Wang Yong Yang Hui Fang Jianyang Wang Hao Jing Jianghu Zhang Guangyi Sun Siye Chen Jing Jin Yongwen Song Yueping Liu Bo Chen Shunan Qi Ning Li Yuan Tang Ningning Lu Hua Ren Yexiong Li |
spellingShingle |
Xuran Zhao Yu Tang Shulian Wang Yong Yang Hui Fang Jianyang Wang Hao Jing Jianghu Zhang Guangyi Sun Siye Chen Jing Jin Yongwen Song Yueping Liu Bo Chen Shunan Qi Ning Li Yuan Tang Ningning Lu Hua Ren Yexiong Li Locoregional recurrence patterns in women with breast cancer who have not undergone post-mastectomy radiotherapy Radiation Oncology Breast neoplasm Mastectomy Locoregional recurrence Risk factors |
author_facet |
Xuran Zhao Yu Tang Shulian Wang Yong Yang Hui Fang Jianyang Wang Hao Jing Jianghu Zhang Guangyi Sun Siye Chen Jing Jin Yongwen Song Yueping Liu Bo Chen Shunan Qi Ning Li Yuan Tang Ningning Lu Hua Ren Yexiong Li |
author_sort |
Xuran Zhao |
title |
Locoregional recurrence patterns in women with breast cancer who have not undergone post-mastectomy radiotherapy |
title_short |
Locoregional recurrence patterns in women with breast cancer who have not undergone post-mastectomy radiotherapy |
title_full |
Locoregional recurrence patterns in women with breast cancer who have not undergone post-mastectomy radiotherapy |
title_fullStr |
Locoregional recurrence patterns in women with breast cancer who have not undergone post-mastectomy radiotherapy |
title_full_unstemmed |
Locoregional recurrence patterns in women with breast cancer who have not undergone post-mastectomy radiotherapy |
title_sort |
locoregional recurrence patterns in women with breast cancer who have not undergone post-mastectomy radiotherapy |
publisher |
BMC |
series |
Radiation Oncology |
issn |
1748-717X |
publishDate |
2020-09-01 |
description |
Abstract Background To analyze the patterns of locoregional recurrence in breast cancer patients after mastectomy. Methods The retrospective study included 7073 women with breast cancer without post-mastectomy radiotherapy: 4604 (65.1%) had pT1–2 N0 disease (low risk); 2042 (28.9%), pT1–2 N1 (intermediate risk); and 427 (6.0%), pT3–4 and/or pN2–3, or pT1–2 N1 after neoadjuvant chemotherapy (high risk). The distribution of cumulative locoregional recurrence was analyzed. The local recurrence and regional recurrence rates were estimated by the Kaplan-Meier method, and differences were compared with the log-rank test. Multivariate analysis was performed using Cox logistic regression analysis. Results In the median follow-up of 63.0 months, 469 patients had locoregional recurrence: chest wall recurrence in 238 (50.7%) cases, supraclavicular/infraclavicular nodes in 236 (50.3%) cases, axilla in 92 (19.6%), and internal mammary nodes in 50 (10.7%) cases. The 5-year local recurrence and regional recurrence rates were 2.5 and 4.4%, respectively. Subgroup analysis of the three risk groups and five molecular subtypes (luminal A, luminal B-Her2 negative, luminal B-Her2 positive, Her2-enriched, and triple negative) also showed that the chest wall and supraclavicular/infraclavicular nodes were the most common recurrence sites. Age, tumor location, T stage, N stage, and hormone receptor status were independent prognostic factors for both local recurrence and regional recurrence (p < 0.05). Conclusions The chest wall and supraclavicular/infraclavicular nodes are common sites of locoregional recurrence in breast cancer, irrespective of disease stage or molecular subtype, and the prognostic factors for local recurrence and regional recurrence are similar. Therefore, chest wall and supraclavicular/infraclavicular nodes irradiation should always be considered in post-mastectomy radiotherapy. |
topic |
Breast neoplasm Mastectomy Locoregional recurrence Risk factors |
url |
http://link.springer.com/article/10.1186/s13014-020-01637-w |
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doaj-f5c0e321807540e398c3793bfae0c2062020-11-25T03:02:40ZengBMCRadiation Oncology1748-717X2020-09-0115111210.1186/s13014-020-01637-wLocoregional recurrence patterns in women with breast cancer who have not undergone post-mastectomy radiotherapyXuran Zhao0Yu Tang1Shulian Wang2Yong Yang3Hui Fang4Jianyang Wang5Hao Jing6Jianghu Zhang7Guangyi Sun8Siye Chen9Jing Jin10Yongwen Song11Yueping Liu12Bo Chen13Shunan Qi14Ning Li15Yuan Tang16Ningning Lu17Hua Ren18Yexiong Li19Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Background To analyze the patterns of locoregional recurrence in breast cancer patients after mastectomy. Methods The retrospective study included 7073 women with breast cancer without post-mastectomy radiotherapy: 4604 (65.1%) had pT1–2 N0 disease (low risk); 2042 (28.9%), pT1–2 N1 (intermediate risk); and 427 (6.0%), pT3–4 and/or pN2–3, or pT1–2 N1 after neoadjuvant chemotherapy (high risk). The distribution of cumulative locoregional recurrence was analyzed. The local recurrence and regional recurrence rates were estimated by the Kaplan-Meier method, and differences were compared with the log-rank test. Multivariate analysis was performed using Cox logistic regression analysis. Results In the median follow-up of 63.0 months, 469 patients had locoregional recurrence: chest wall recurrence in 238 (50.7%) cases, supraclavicular/infraclavicular nodes in 236 (50.3%) cases, axilla in 92 (19.6%), and internal mammary nodes in 50 (10.7%) cases. The 5-year local recurrence and regional recurrence rates were 2.5 and 4.4%, respectively. Subgroup analysis of the three risk groups and five molecular subtypes (luminal A, luminal B-Her2 negative, luminal B-Her2 positive, Her2-enriched, and triple negative) also showed that the chest wall and supraclavicular/infraclavicular nodes were the most common recurrence sites. Age, tumor location, T stage, N stage, and hormone receptor status were independent prognostic factors for both local recurrence and regional recurrence (p < 0.05). Conclusions The chest wall and supraclavicular/infraclavicular nodes are common sites of locoregional recurrence in breast cancer, irrespective of disease stage or molecular subtype, and the prognostic factors for local recurrence and regional recurrence are similar. Therefore, chest wall and supraclavicular/infraclavicular nodes irradiation should always be considered in post-mastectomy radiotherapy.http://link.springer.com/article/10.1186/s13014-020-01637-wBreast neoplasmMastectomyLocoregional recurrenceRisk factors |