Current Status and Progression of Endocrinotherapy for Prostate Cancer in the View of Translational Medicine
Prostate cancer is a common malignant tumor in urological system. It is also the second leading cause of high morbidity and mortality among men in Western countries. The occurrence and development of prostate cancer is a multi-factor and multi-step process involving changes of numerous genes from th...
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doaj-f5c4c83077774eeaa6aee6cbcaeba2202020-11-25T00:46:49ZengThird Party Medicine International Publishing Group Co. Limited Journal of International Translational Medicine 2227-63942016-09-014316016610.11910/2227-6394.2016.04.03.03JITM2016040303Current Status and Progression of Endocrinotherapy for Prostate Cancer in the View of Translational MedicineLi-ya QIAN0Hai-ling MA1Xiao-feng CHEN2Jun XIE3Department of Endocrinology, Zhangjiagang Hospital of Traditional Chinese Medicine, Zhangjiagang, Jiangsu, 215600, ChinaDepartment of Pharmacy, Zhangjiagang Hospital of Traditional Chinese Medicine, Zhangjiagang, Jiangsu, 215600, ChinaDepartment of Pharmacy, Zhangjiagang Hospital of Traditional Chinese Medicine, Zhangjiagang, Jiangsu, 215600, ChinaDepartment of Pharmacy, Zhangjiagang Hospital of Traditional Chinese Medicine, Zhangjiagang, Jiangsu, 215600, ChinaProstate cancer is a common malignant tumor in urological system. It is also the second leading cause of high morbidity and mortality among men in Western countries. The occurrence and development of prostate cancer is a multi-factor and multi-step process involving changes of numerous genes from the aspect of molecular genetics. In the last decades, translational medicine has discovered that numerous basic research specific to the prevention, diagnosis and treatment of prostate cancer has broaden the application prospect, especially endocrinotherapy, which is of great importance in the treatment of prostate cancer. This study mainly reviewed the mechanism, indications and therapeutic protocols of endocrinotherapy, including castration treatment, anti-androgen treatment, maximal androgen blockade (MAB), intermittent hormonal therapy (IHT), neoadjuvant hormonal therapy (NHT) and adjuvant hormonal therapy (AHT), aiming to provide references for the clinical treatment of prostate cancer.http://www.jitm.hk/EN/abstract/abstract212.shtmlProstate cancerCastration treatmentAnti-androgen treatmentMaximal androgen blockadeIntermittent hormonal therapyNeoadjuvant hormonal therapyAdjuvant hormonal therapyTranslational medicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Li-ya QIAN Hai-ling MA Xiao-feng CHEN Jun XIE |
spellingShingle |
Li-ya QIAN Hai-ling MA Xiao-feng CHEN Jun XIE Current Status and Progression of Endocrinotherapy for Prostate Cancer in the View of Translational Medicine Journal of International Translational Medicine Prostate cancer Castration treatment Anti-androgen treatment Maximal androgen blockade Intermittent hormonal therapy Neoadjuvant hormonal therapy Adjuvant hormonal therapy Translational medicine |
author_facet |
Li-ya QIAN Hai-ling MA Xiao-feng CHEN Jun XIE |
author_sort |
Li-ya QIAN |
title |
Current Status and Progression of Endocrinotherapy for Prostate Cancer in the View of Translational Medicine |
title_short |
Current Status and Progression of Endocrinotherapy for Prostate Cancer in the View of Translational Medicine |
title_full |
Current Status and Progression of Endocrinotherapy for Prostate Cancer in the View of Translational Medicine |
title_fullStr |
Current Status and Progression of Endocrinotherapy for Prostate Cancer in the View of Translational Medicine |
title_full_unstemmed |
Current Status and Progression of Endocrinotherapy for Prostate Cancer in the View of Translational Medicine |
title_sort |
current status and progression of endocrinotherapy for prostate cancer in the view of translational medicine |
publisher |
Third Party Medicine International Publishing Group Co. Limited |
series |
Journal of International Translational Medicine |
issn |
2227-6394 |
publishDate |
2016-09-01 |
description |
Prostate cancer is a common malignant tumor in urological system. It is also the second leading cause of high morbidity and mortality among men in Western countries. The occurrence and development of prostate cancer is a multi-factor and multi-step process involving changes of numerous genes from the aspect of molecular genetics. In the last decades, translational medicine has discovered that numerous basic research specific to the prevention, diagnosis and treatment of prostate cancer has broaden the application prospect, especially endocrinotherapy, which is of great importance in the treatment of prostate cancer. This study mainly reviewed the mechanism, indications and therapeutic protocols of endocrinotherapy, including castration treatment, anti-androgen treatment, maximal androgen blockade (MAB), intermittent hormonal therapy (IHT), neoadjuvant hormonal therapy (NHT) and adjuvant hormonal therapy (AHT), aiming to provide references for the clinical treatment of prostate cancer. |
topic |
Prostate cancer Castration treatment Anti-androgen treatment Maximal androgen blockade Intermittent hormonal therapy Neoadjuvant hormonal therapy Adjuvant hormonal therapy Translational medicine |
url |
http://www.jitm.hk/EN/abstract/abstract212.shtml |
work_keys_str_mv |
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