Prognostic Value of the Neutrophil-to-Lymphocyte Ratio before and after Radiotherapy for Anaplastic Thyroid Carcinoma

• Main Authors: Jiyun Park, Jun Park, Jung Hee Shin, Young Lyun Oh, Hyun Ae Jung, Man Ki Chung, Jun-Ho Choe, Yong Chan Ahn, Sun Wook Kim, Jae Hoon Chung, Tae Hyuk Kim, Jae Myoung Noh
• Format: Article
• Language: English
• Published: MDPI AG 2021-04-01
• Series: Cancers
• Subjects: anaplastic thyroid carcinoma; neutrophil-to-lymphocyte ratio; neutrophil; lymphocyte; radiotherapy
• Online Access: https://www.mdpi.com/2072-6694/13/8/1913

The neutrophil–lymphocyte ratio (NLR) is a marker of systemic inflammation, and its elevation has recently been associated with poor survival in many solid cancers. Leukocyte elevation and lymphocyte reduction are associated with a poor response to radiotherapy (RT). This study aimed to assess the prognostic value of NLR before and after RT for anaplastic thyroid carcinoma (ATC). This retrospective study analyzed 40 patients with ATC who received RT with available complete blood cell count data from November 1995 through May 2020 at Samsung Medical Center (Seoul, Korea). Patients were classified into two groups according to the NLR before and after RT. The median overall survival (OS) was 8.9 months (range, 3.5–18.2) in the low NLR group (<3.47) and 5.2 months (range, 2.7–7.5) months in the high NLR group (≥3.47). The association between NLR and OS was also observed in multivariable Cox regression analysis (hazard ratio, 3.18; 95% confidence interval, 1.15–8.85; <i>p</i> = 0.026). The OS curves differed significantly according to post-RT NLR (<i>p</i> = 0.036). A high NLR before and after RT may be significantly associated with poor OS in patients with ATC who receive RT.