Wnt Signaling Pathway and Chronic Myelogenous Leukemia
As a type of cancer that starts in certain blood-forming cells of the bone marrow, chronic myeloid leukemia (CML) is caused by the formation of an abnormal gene called BCR-ABL1. The targeted medicine TKI for BCR-ABL1 has great effect on treating CML: however, TKI is not able to completely remove the...
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Magazine House of Cancer Research on Prevention and Treatment
2019-02-01
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doaj-f5d12377da7c4b93a940c1b72a7c1d702020-11-25T02:11:55ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782019-02-0146217417710.3971/j.issn.1000-8578.2019.18.08998578.2019.18.0899Wnt Signaling Pathway and Chronic Myelogenous LeukemiaHOU Yan0LI Wenqian1FENG Jianming2AI Guo3XIE Youbang4HUA Qingcuo5ZHAO Changming6Graduate School, Qinghai University, Xi' ning 810016, ChinaDepartment of Blood Rheumatology, Qinghai Provincial People's Hospital, Xi'ning 810007, ChinaDepartment of Blood Rheumatology, Qinghai Provincial People's Hospital, Xi'ning 810007, ChinaDepartment of Blood Rheumatology, Qinghai Provincial People's Hospital, Xi'ning 810007, ChinaDepartment of Blood Rheumatology, Qinghai Provincial People's Hospital, Xi'ning 810007, ChinaDepartment of Blood Rheumatology, Qinghai Provincial People's Hospital, Xi'ning 810007, ChinaGraduate School, Qinghai University, Xi' ning 810016, ChinaAs a type of cancer that starts in certain blood-forming cells of the bone marrow, chronic myeloid leukemia (CML) is caused by the formation of an abnormal gene called BCR-ABL1. The targeted medicine TKI for BCR-ABL1 has great effect on treating CML: however, TKI is not able to completely remove the leukemia stem cells (LSCs) in CML patients, which will lead to drug resistance and leukemia relapse. With the application of Wnt signaling pathway in regulating stem cell function, many studies have found that it also plays an important role in treating CML. In this paper, we reviewed the impact of Wnt signaling pathway on CML therapy.http://html.rhhz.net/ZLFZYJ/html/8578.2019.18.0899.htmchronic myelogenous leukemiawntleukemia stem celltki |
collection |
DOAJ |
language |
zho |
format |
Article |
sources |
DOAJ |
author |
HOU Yan LI Wenqian FENG Jianming AI Guo XIE Youbang HUA Qingcuo ZHAO Changming |
spellingShingle |
HOU Yan LI Wenqian FENG Jianming AI Guo XIE Youbang HUA Qingcuo ZHAO Changming Wnt Signaling Pathway and Chronic Myelogenous Leukemia Zhongliu Fangzhi Yanjiu chronic myelogenous leukemia wnt leukemia stem cell tki |
author_facet |
HOU Yan LI Wenqian FENG Jianming AI Guo XIE Youbang HUA Qingcuo ZHAO Changming |
author_sort |
HOU Yan |
title |
Wnt Signaling Pathway and Chronic Myelogenous Leukemia |
title_short |
Wnt Signaling Pathway and Chronic Myelogenous Leukemia |
title_full |
Wnt Signaling Pathway and Chronic Myelogenous Leukemia |
title_fullStr |
Wnt Signaling Pathway and Chronic Myelogenous Leukemia |
title_full_unstemmed |
Wnt Signaling Pathway and Chronic Myelogenous Leukemia |
title_sort |
wnt signaling pathway and chronic myelogenous leukemia |
publisher |
Magazine House of Cancer Research on Prevention and Treatment |
series |
Zhongliu Fangzhi Yanjiu |
issn |
1000-8578 1000-8578 |
publishDate |
2019-02-01 |
description |
As a type of cancer that starts in certain blood-forming cells of the bone marrow, chronic myeloid leukemia (CML) is caused by the formation of an abnormal gene called BCR-ABL1. The targeted medicine TKI for BCR-ABL1 has great effect on treating CML: however, TKI is not able to completely remove the leukemia stem cells (LSCs) in CML patients, which will lead to drug resistance and leukemia relapse. With the application of Wnt signaling pathway in regulating stem cell function, many studies have found that it also plays an important role in treating CML. In this paper, we reviewed the impact of Wnt signaling pathway on CML therapy. |
topic |
chronic myelogenous leukemia wnt leukemia stem cell tki |
url |
http://html.rhhz.net/ZLFZYJ/html/8578.2019.18.0899.htm |
work_keys_str_mv |
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1724911861474787328 |