The effectiveness of long-term course of Sterimar Mn nasal spray for treatment of the recurrence rates of acute allergic rhinitis in patients with chronic allergic rhinitis
Michele Grasso,1 Marco de Vincentiis,1 Griselda Agolli,1 Francesco Cilurzo,2 Raffaele Grasso2 1ENT Department, Head and Neck Surgery, University “Sapienza”, Rome, Italy; 2ENT Department, Head and Neck Surgery, Lamezia Terme Hospital, Calabria, Italy Background: The “c...
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doaj-f5d82f05078843f287847f14067a05662020-11-24T21:36:35ZengDove Medical PressDrug Design, Development and Therapy1177-88812018-04-01Volume 1270570937551The effectiveness of long-term course of Sterimar Mn nasal spray for treatment of the recurrence rates of acute allergic rhinitis in patients with chronic allergic rhinitisGrasso Mde Vincentiis MAgolli GCilurzo FGrasso RMichele Grasso,1 Marco de Vincentiis,1 Griselda Agolli,1 Francesco Cilurzo,2 Raffaele Grasso2 1ENT Department, Head and Neck Surgery, University “Sapienza”, Rome, Italy; 2ENT Department, Head and Neck Surgery, Lamezia Terme Hospital, Calabria, Italy Background: The “cost of illness” of the acute allergic rhinitis (AR) episodes in patients with chronic AR is very high in terms of therapy and quality of life. AR represents a worldwide health problem; despite the fact that many standardized treatments have been proposed and used, the recurrence rate of acute rhinitis episodes in springtime is always higher.Materials and methods: Sixty consecutive patients (13 F and 17 M in group A, 15 F and 15 M in group B; p=0.60) with chronic AR were enrolled in this prospective, controlled clinical trial. Thirty patients were treated daily for the same 5 months of the following year (2013) with isotonic seawater nasal spray enriched with manganese (Sterimar Mn; 4 puffs/day), whereas 30 patients received only the standard care and were used as control group.Results: A 5 months course treatment with the nasal Sterimar Mn was able to decrease, significantly (p<0.001), the number of episodes of acute AR (6.33 episodes in the group of treated patients versus 9.33 episodes in control group). Also, the 5 months quality of life reduced over time (Visual Analogue Scale 5th month 9.90 in treated group versus Visual Analogue Scale 5th month 8.72 in control group: p<0.001) without the typical adverse effects of the AR standard care therapy.Conclusion: This study shows the effectiveness of the use of Sterimar Mn for a 5 months therapy in terms of reduction of the number of episodes of acute AR and effectiveness of intrasubject improvement of Visual Analog Scale (quality of life). Keywords: chronic allergic rhinitis, acute allergic rhinitis, prevention, nasal detersion, Sterimar Mnhttps://www.dovepress.com/the-effectiveness-of-long-term-course-of-sterimar-mn-nasal-spray-for-t-peer-reviewed-article-DDDTChronic Allergic RhinitisAcute Allergic RhinitisPreventionNasal detersionSterimar Mn |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Grasso M de Vincentiis M Agolli G Cilurzo F Grasso R |
spellingShingle |
Grasso M de Vincentiis M Agolli G Cilurzo F Grasso R The effectiveness of long-term course of Sterimar Mn nasal spray for treatment of the recurrence rates of acute allergic rhinitis in patients with chronic allergic rhinitis Drug Design, Development and Therapy Chronic Allergic Rhinitis Acute Allergic Rhinitis Prevention Nasal detersion Sterimar Mn |
author_facet |
Grasso M de Vincentiis M Agolli G Cilurzo F Grasso R |
author_sort |
Grasso M |
title |
The effectiveness of long-term course of Sterimar Mn nasal spray for treatment of the recurrence rates of acute allergic rhinitis in patients with chronic allergic rhinitis |
title_short |
The effectiveness of long-term course of Sterimar Mn nasal spray for treatment of the recurrence rates of acute allergic rhinitis in patients with chronic allergic rhinitis |
title_full |
The effectiveness of long-term course of Sterimar Mn nasal spray for treatment of the recurrence rates of acute allergic rhinitis in patients with chronic allergic rhinitis |
title_fullStr |
The effectiveness of long-term course of Sterimar Mn nasal spray for treatment of the recurrence rates of acute allergic rhinitis in patients with chronic allergic rhinitis |
title_full_unstemmed |
The effectiveness of long-term course of Sterimar Mn nasal spray for treatment of the recurrence rates of acute allergic rhinitis in patients with chronic allergic rhinitis |
title_sort |
effectiveness of long-term course of sterimar mn nasal spray for treatment of the recurrence rates of acute allergic rhinitis in patients with chronic allergic rhinitis |
publisher |
Dove Medical Press |
series |
Drug Design, Development and Therapy |
issn |
1177-8881 |
publishDate |
2018-04-01 |
description |
Michele Grasso,1 Marco de Vincentiis,1 Griselda Agolli,1 Francesco Cilurzo,2 Raffaele Grasso2 1ENT Department, Head and Neck Surgery, University “Sapienza”, Rome, Italy; 2ENT Department, Head and Neck Surgery, Lamezia Terme Hospital, Calabria, Italy Background: The “cost of illness” of the acute allergic rhinitis (AR) episodes in patients with chronic AR is very high in terms of therapy and quality of life. AR represents a worldwide health problem; despite the fact that many standardized treatments have been proposed and used, the recurrence rate of acute rhinitis episodes in springtime is always higher.Materials and methods: Sixty consecutive patients (13 F and 17 M in group A, 15 F and 15 M in group B; p=0.60) with chronic AR were enrolled in this prospective, controlled clinical trial. Thirty patients were treated daily for the same 5 months of the following year (2013) with isotonic seawater nasal spray enriched with manganese (Sterimar Mn; 4 puffs/day), whereas 30 patients received only the standard care and were used as control group.Results: A 5 months course treatment with the nasal Sterimar Mn was able to decrease, significantly (p<0.001), the number of episodes of acute AR (6.33 episodes in the group of treated patients versus 9.33 episodes in control group). Also, the 5 months quality of life reduced over time (Visual Analogue Scale 5th month 9.90 in treated group versus Visual Analogue Scale 5th month 8.72 in control group: p<0.001) without the typical adverse effects of the AR standard care therapy.Conclusion: This study shows the effectiveness of the use of Sterimar Mn for a 5 months therapy in terms of reduction of the number of episodes of acute AR and effectiveness of intrasubject improvement of Visual Analog Scale (quality of life). Keywords: chronic allergic rhinitis, acute allergic rhinitis, prevention, nasal detersion, Sterimar Mn |
topic |
Chronic Allergic Rhinitis Acute Allergic Rhinitis Prevention Nasal detersion Sterimar Mn |
url |
https://www.dovepress.com/the-effectiveness-of-long-term-course-of-sterimar-mn-nasal-spray-for-t-peer-reviewed-article-DDDT |
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