Current state and future possibilities of ovarian tissue transplantation
Abstract Background As a result of recent developments in cancer treatment, cancer survivorship and survivors' quality of life have been emphasized. Although ovarian tissue cryopreservation (OTC) is an experimental technique, it would be the sole technique for fertility preservation treatment f...
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Online Access: | https://doi.org/10.1002/rmb2.12268 |
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doaj-f5e2c3ec73b04673b6a1a5ad56b8aad42020-11-24T21:34:29ZengWileyReproductive Medicine and Biology1445-57811447-05782019-07-0118321722410.1002/rmb2.12268Current state and future possibilities of ovarian tissue transplantationSeido Takae0Nao Suzuki1Department of Obstetrics and Gynecology St. Marianna University School of Medicine Kawasaki City JapanDepartment of Obstetrics and Gynecology St. Marianna University School of Medicine Kawasaki City JapanAbstract Background As a result of recent developments in cancer treatment, cancer survivorship and survivors' quality of life have been emphasized. Although ovarian tissue cryopreservation (OTC) is an experimental technique, it would be the sole technique for fertility preservation treatment for girls with malignant disease. Indeed, OTC requires ovarian tissue transplantation (OTT) for conception. As for OTC, there is room to investigate OTT. The present review focused on the current state and progress of OTT. Method The literature regarding OTT, which is currently under development, was reviewed. Main findings To improve the outcome of OTT, both efficacy and safety are important. Good surgical technique and the optimal site are important surgical factors, with orthotopic transplantation increasing. Treatment of growth factors, gonadotropins, antioxidants, apoptosis suppression factors, and cell therapy may improve the efficacy of OTT by inducing neo‐angiogenesis and preventing damage. Artificial ovaries, complete in vitro primordial follicle culture technique, and non‐invasive ovarian imaging techniques, such as optical coherence tomography, to select the best ovarian tissue are future possibilities. Conclusion Improving neo‐angiogenesis and preventing damage with optimization, as well as investigation of future techniques, may bring us to the next stage of a fertility preservation strategy.https://doi.org/10.1002/rmb2.12268fertility preservationin vitro oocyte maturation techniquesinvestigative techniquestissue and organ harvestingtransplantation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Seido Takae Nao Suzuki |
spellingShingle |
Seido Takae Nao Suzuki Current state and future possibilities of ovarian tissue transplantation Reproductive Medicine and Biology fertility preservation in vitro oocyte maturation techniques investigative techniques tissue and organ harvesting transplantation |
author_facet |
Seido Takae Nao Suzuki |
author_sort |
Seido Takae |
title |
Current state and future possibilities of ovarian tissue transplantation |
title_short |
Current state and future possibilities of ovarian tissue transplantation |
title_full |
Current state and future possibilities of ovarian tissue transplantation |
title_fullStr |
Current state and future possibilities of ovarian tissue transplantation |
title_full_unstemmed |
Current state and future possibilities of ovarian tissue transplantation |
title_sort |
current state and future possibilities of ovarian tissue transplantation |
publisher |
Wiley |
series |
Reproductive Medicine and Biology |
issn |
1445-5781 1447-0578 |
publishDate |
2019-07-01 |
description |
Abstract Background As a result of recent developments in cancer treatment, cancer survivorship and survivors' quality of life have been emphasized. Although ovarian tissue cryopreservation (OTC) is an experimental technique, it would be the sole technique for fertility preservation treatment for girls with malignant disease. Indeed, OTC requires ovarian tissue transplantation (OTT) for conception. As for OTC, there is room to investigate OTT. The present review focused on the current state and progress of OTT. Method The literature regarding OTT, which is currently under development, was reviewed. Main findings To improve the outcome of OTT, both efficacy and safety are important. Good surgical technique and the optimal site are important surgical factors, with orthotopic transplantation increasing. Treatment of growth factors, gonadotropins, antioxidants, apoptosis suppression factors, and cell therapy may improve the efficacy of OTT by inducing neo‐angiogenesis and preventing damage. Artificial ovaries, complete in vitro primordial follicle culture technique, and non‐invasive ovarian imaging techniques, such as optical coherence tomography, to select the best ovarian tissue are future possibilities. Conclusion Improving neo‐angiogenesis and preventing damage with optimization, as well as investigation of future techniques, may bring us to the next stage of a fertility preservation strategy. |
topic |
fertility preservation in vitro oocyte maturation techniques investigative techniques tissue and organ harvesting transplantation |
url |
https://doi.org/10.1002/rmb2.12268 |
work_keys_str_mv |
AT seidotakae currentstateandfuturepossibilitiesofovariantissuetransplantation AT naosuzuki currentstateandfuturepossibilitiesofovariantissuetransplantation |
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