Dopaminergic Modulation of Goal-Directed Behavior in a Rodent Model of Attention-Deficit/Hyperactivity Disorder
Aside from its clinical symptoms of inattention, impulsivity and hyperactivity, patients with Attention/Deficit-Hyperactivity Disorder (ADHD) display reward and motivational impairments. These impairments may reflect a deficit in action control, that is, an inability to flexibly adapt behavior to ch...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-10-01
|
Series: | Frontiers in Integrative Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fnint.2018.00045/full |
id |
doaj-f5ee8020206b474ea92a86c8919435f2 |
---|---|
record_format |
Article |
spelling |
doaj-f5ee8020206b474ea92a86c8919435f22020-11-24T21:47:54ZengFrontiers Media S.A.Frontiers in Integrative Neuroscience1662-51452018-10-011210.3389/fnint.2018.00045408549Dopaminergic Modulation of Goal-Directed Behavior in a Rodent Model of Attention-Deficit/Hyperactivity DisorderJoman Y. Natsheh0Joman Y. Natsheh1Joman Y. Natsheh2Joman Y. Natsheh3Michael W. Shiflett4Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, United StatesKessler Foundation, East Hanover, NJ, United StatesPalestinian Neuroscience Initiative, Al-Quds University, East Jerusalem, PalestineChildren’s Specialized Hospital Research Center, New Brunswick, NJ, United StatesDepartment of Psychology, Rutgers University, Newark, NJ, United StatesAside from its clinical symptoms of inattention, impulsivity and hyperactivity, patients with Attention/Deficit-Hyperactivity Disorder (ADHD) display reward and motivational impairments. These impairments may reflect a deficit in action control, that is, an inability to flexibly adapt behavior to changing consequences. We previously showed that spontaneously hypertensive rats (SHR), an inbred rodent model of ADHD, show impairments in goal-directed action control, and instead are predominated by habits. In this study, we examined the effects of specific dopamine receptor sub-type (D1 and D2) agonists and antagonists on goal-directed behavior in SHR and the normotensive inbred control strain Wistar-Kyoto (WKY) rats. Rats acquired an instrumental response for different-flavored food rewards. A selective-satiety outcome devaluation procedure followed by a choice test in extinction revealed outcome-insensitive habitual behavior in SHR rats. Outcome-sensitive goal-directed behavior was restored in SHR rats following injection prior to the choice test of the dopamine D2 receptor agonist Quinpirole or dopamine D1 receptor antagonist SCH23390, whereas WKY rats showed habitual responding following exposure to these drugs. This novel finding indicates that the core behavioral deficit in ADHD might not be a consequence of dopamine hypofunction, but rather is due to a misbalance between activation of dopamine D1 and D2 receptor pathways that govern action control.https://www.frontiersin.org/article/10.3389/fnint.2018.00045/fullattention deficit hyperactivity disorderspontaneous hypertensive ratsWistar-Kyoto ratsgoal-directed behaviorhabitual behavioraction control |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joman Y. Natsheh Joman Y. Natsheh Joman Y. Natsheh Joman Y. Natsheh Michael W. Shiflett |
spellingShingle |
Joman Y. Natsheh Joman Y. Natsheh Joman Y. Natsheh Joman Y. Natsheh Michael W. Shiflett Dopaminergic Modulation of Goal-Directed Behavior in a Rodent Model of Attention-Deficit/Hyperactivity Disorder Frontiers in Integrative Neuroscience attention deficit hyperactivity disorder spontaneous hypertensive rats Wistar-Kyoto rats goal-directed behavior habitual behavior action control |
author_facet |
Joman Y. Natsheh Joman Y. Natsheh Joman Y. Natsheh Joman Y. Natsheh Michael W. Shiflett |
author_sort |
Joman Y. Natsheh |
title |
Dopaminergic Modulation of Goal-Directed Behavior in a Rodent Model of Attention-Deficit/Hyperactivity Disorder |
title_short |
Dopaminergic Modulation of Goal-Directed Behavior in a Rodent Model of Attention-Deficit/Hyperactivity Disorder |
title_full |
Dopaminergic Modulation of Goal-Directed Behavior in a Rodent Model of Attention-Deficit/Hyperactivity Disorder |
title_fullStr |
Dopaminergic Modulation of Goal-Directed Behavior in a Rodent Model of Attention-Deficit/Hyperactivity Disorder |
title_full_unstemmed |
Dopaminergic Modulation of Goal-Directed Behavior in a Rodent Model of Attention-Deficit/Hyperactivity Disorder |
title_sort |
dopaminergic modulation of goal-directed behavior in a rodent model of attention-deficit/hyperactivity disorder |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Integrative Neuroscience |
issn |
1662-5145 |
publishDate |
2018-10-01 |
description |
Aside from its clinical symptoms of inattention, impulsivity and hyperactivity, patients with Attention/Deficit-Hyperactivity Disorder (ADHD) display reward and motivational impairments. These impairments may reflect a deficit in action control, that is, an inability to flexibly adapt behavior to changing consequences. We previously showed that spontaneously hypertensive rats (SHR), an inbred rodent model of ADHD, show impairments in goal-directed action control, and instead are predominated by habits. In this study, we examined the effects of specific dopamine receptor sub-type (D1 and D2) agonists and antagonists on goal-directed behavior in SHR and the normotensive inbred control strain Wistar-Kyoto (WKY) rats. Rats acquired an instrumental response for different-flavored food rewards. A selective-satiety outcome devaluation procedure followed by a choice test in extinction revealed outcome-insensitive habitual behavior in SHR rats. Outcome-sensitive goal-directed behavior was restored in SHR rats following injection prior to the choice test of the dopamine D2 receptor agonist Quinpirole or dopamine D1 receptor antagonist SCH23390, whereas WKY rats showed habitual responding following exposure to these drugs. This novel finding indicates that the core behavioral deficit in ADHD might not be a consequence of dopamine hypofunction, but rather is due to a misbalance between activation of dopamine D1 and D2 receptor pathways that govern action control. |
topic |
attention deficit hyperactivity disorder spontaneous hypertensive rats Wistar-Kyoto rats goal-directed behavior habitual behavior action control |
url |
https://www.frontiersin.org/article/10.3389/fnint.2018.00045/full |
work_keys_str_mv |
AT jomanynatsheh dopaminergicmodulationofgoaldirectedbehaviorinarodentmodelofattentiondeficithyperactivitydisorder AT jomanynatsheh dopaminergicmodulationofgoaldirectedbehaviorinarodentmodelofattentiondeficithyperactivitydisorder AT jomanynatsheh dopaminergicmodulationofgoaldirectedbehaviorinarodentmodelofattentiondeficithyperactivitydisorder AT jomanynatsheh dopaminergicmodulationofgoaldirectedbehaviorinarodentmodelofattentiondeficithyperactivitydisorder AT michaelwshiflett dopaminergicmodulationofgoaldirectedbehaviorinarodentmodelofattentiondeficithyperactivitydisorder |
_version_ |
1725894702060797952 |