A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination
The Hippo pathway has recently been implicated in Schwann cell (SC) development and myelination. Here the authors reveal mechanistic insights into how TAZ and YAP regulate and interact with target genes; they further identify a negative feedback loop between TAZ/YAP and G protein Gαs that balances S...
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| Language: | English |
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Nature Publishing Group
2017-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15161 |
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doaj-f5f8fdceb6a04ad79e3da71f80933ff22021-05-11T07:18:33ZengNature Publishing GroupNature Communications2041-17232017-04-018111510.1038/ncomms15161A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelinationYaqi Deng0Lai Man Natalie Wu1Shujun Bai2Chuntao Zhao3Haibo Wang4Jincheng Wang5Lingli Xu6Masahide Sakabe7Wenhao Zhou8Mei Xin9Q. Richard Lu10Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical CenterDivision of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical CenterKey Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan UniversityDivision of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical CenterDivision of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical CenterDivision of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical CenterKey Laboratory of Birth Defects, Children’s Hospital of Fudan UniversityDivision of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical CenterKey Laboratory of Birth Defects, Children’s Hospital of Fudan UniversityDivision of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical CenterDivision of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical CenterThe Hippo pathway has recently been implicated in Schwann cell (SC) development and myelination. Here the authors reveal mechanistic insights into how TAZ and YAP regulate and interact with target genes; they further identify a negative feedback loop between TAZ/YAP and G protein Gαs that balances SC proliferation and differentiation.https://doi.org/10.1038/ncomms15161 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yaqi Deng Lai Man Natalie Wu Shujun Bai Chuntao Zhao Haibo Wang Jincheng Wang Lingli Xu Masahide Sakabe Wenhao Zhou Mei Xin Q. Richard Lu |
| spellingShingle |
Yaqi Deng Lai Man Natalie Wu Shujun Bai Chuntao Zhao Haibo Wang Jincheng Wang Lingli Xu Masahide Sakabe Wenhao Zhou Mei Xin Q. Richard Lu A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination Nature Communications |
| author_facet |
Yaqi Deng Lai Man Natalie Wu Shujun Bai Chuntao Zhao Haibo Wang Jincheng Wang Lingli Xu Masahide Sakabe Wenhao Zhou Mei Xin Q. Richard Lu |
| author_sort |
Yaqi Deng |
| title |
A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination |
| title_short |
A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination |
| title_full |
A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination |
| title_fullStr |
A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination |
| title_full_unstemmed |
A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination |
| title_sort |
reciprocal regulatory loop between taz/yap and g-protein gαs regulates schwann cell proliferation and myelination |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-04-01 |
| description |
The Hippo pathway has recently been implicated in Schwann cell (SC) development and myelination. Here the authors reveal mechanistic insights into how TAZ and YAP regulate and interact with target genes; they further identify a negative feedback loop between TAZ/YAP and G protein Gαs that balances SC proliferation and differentiation. |
| url |
https://doi.org/10.1038/ncomms15161 |
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