Down Presymptomatic View of Dementia Characteristics
Down syndrome (DS) is caused by complete or segmental chromosome 21 trisomy that results in neurodegeneration and progressive intellectual disability. Abnormal function in the prefrontal cortex, cerebellum, and hippocampus are the main reasons for cognitive deficits in DS that result in impaired cog...
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Shahid Beheshti University of Medical Sciences
2020-01-01
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doaj-f5fe95cc5e2d41beabbf9066e63171de2020-11-25T01:31:02ZengShahid Beheshti University of Medical SciencesInternational Clinical Neuroscience Journal2383-18712383-20962020-01-01711510.15171/icnj.2020.01icnj-4149Down Presymptomatic View of Dementia CharacteristicsMohammad Amin Joshaghanian0Sassan Mohammadi1Zohreh Gholizadeh Ghozloujeh2Mehrdad Farahani3Kurosh Mojtabavi4School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran IranSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran IranSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran IranSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran IranCellular and Molecular Research Center & Department of Physiology, School of Medicine, Guilan University of Medical Sciences, Rasht, IranDown syndrome (DS) is caused by complete or segmental chromosome 21 trisomy that results in neurodegeneration and progressive intellectual disability. Abnormal function in the prefrontal cortex, cerebellum, and hippocampus are the main reasons for cognitive deficits in DS that result in impaired cognitive function, delayed speech and language, learning and memory disability, and behavioral and emotional disorders. There is no specific treatment for DS, and our understanding of the mechanisms of the disorder is incomplete and causes to hamper the development of effective therapies regarding the development of neuropathology and memory loss in DS. Here, we review the literature on cognitive functioning, unique characteristics, environmental considerations, and recent findings on Alzheimer’s disease in DS.http://journals.sbmu.ac.ir/Neuroscience/article/download/27304/1down syndrome (ds)dementiaalzheimer’s diseasecognitive deficitsneurodegeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Amin Joshaghanian Sassan Mohammadi Zohreh Gholizadeh Ghozloujeh Mehrdad Farahani Kurosh Mojtabavi |
spellingShingle |
Mohammad Amin Joshaghanian Sassan Mohammadi Zohreh Gholizadeh Ghozloujeh Mehrdad Farahani Kurosh Mojtabavi Down Presymptomatic View of Dementia Characteristics International Clinical Neuroscience Journal down syndrome (ds) dementia alzheimer’s disease cognitive deficits neurodegeneration |
author_facet |
Mohammad Amin Joshaghanian Sassan Mohammadi Zohreh Gholizadeh Ghozloujeh Mehrdad Farahani Kurosh Mojtabavi |
author_sort |
Mohammad Amin Joshaghanian |
title |
Down Presymptomatic View of Dementia Characteristics |
title_short |
Down Presymptomatic View of Dementia Characteristics |
title_full |
Down Presymptomatic View of Dementia Characteristics |
title_fullStr |
Down Presymptomatic View of Dementia Characteristics |
title_full_unstemmed |
Down Presymptomatic View of Dementia Characteristics |
title_sort |
down presymptomatic view of dementia characteristics |
publisher |
Shahid Beheshti University of Medical Sciences |
series |
International Clinical Neuroscience Journal |
issn |
2383-1871 2383-2096 |
publishDate |
2020-01-01 |
description |
Down syndrome (DS) is caused by complete or segmental chromosome 21 trisomy that results in neurodegeneration and progressive intellectual disability. Abnormal function in the prefrontal cortex, cerebellum, and hippocampus are the main reasons for cognitive deficits in DS that result in impaired cognitive function, delayed speech and language, learning and memory disability, and behavioral and emotional disorders. There is no specific treatment for DS, and our understanding of the mechanisms of the disorder is incomplete and causes to hamper the development of effective therapies regarding the development of neuropathology and memory loss in DS. Here, we review the literature on cognitive functioning, unique characteristics, environmental considerations, and recent findings on Alzheimer’s disease in DS. |
topic |
down syndrome (ds) dementia alzheimer’s disease cognitive deficits neurodegeneration |
url |
http://journals.sbmu.ac.ir/Neuroscience/article/download/27304/1 |
work_keys_str_mv |
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1725088216438013952 |