Primary Biliary Cirrhosis in HLA-Identical Twin Sisters

Primary Biliary Cirrhosis in HLA-Identical Twin Sisters

Human leukocyte antigen (HLA)-identical twin sisters with chronic liver disease were evaluated. Both had a childhood history of transient jaundice suggestive of a possible infectious cause. Subsequent studies in both siblings at age 51 years revealed antimitochondrial antibody-positive primary bilia...

Full description

Bibliographic Details
Main Authors: Hugh J Freeman, Robert J Bailey
Format: Article
Language:English
Published: Hindawi Limited 1994-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/1994/954162
id doaj-f6002cfdda314919b8198e81734414b3
record_format Article
spelling doaj-f6002cfdda314919b8198e81734414b32020-11-24T22:49:05ZengHindawi LimitedCanadian Journal of Gastroenterology0835-79001994-01-0182889110.1155/1994/954162Primary Biliary Cirrhosis in HLA-Identical Twin SistersHugh J Freeman0Robert J Bailey1Department of Medicine (Gastroenterology), University Hospital and University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Medicine (Gastroenterology), Royal Alexandra Hospital and University of Alberta, Edmonton, Alberta, CanadaHuman leukocyte antigen (HLA)-identical twin sisters with chronic liver disease were evaluated. Both had a childhood history of transient jaundice suggestive of a possible infectious cause. Subsequent studies in both siblings at age 51 years revealed antimitochondrial antibody-positive primary biliary cirrhosis. This report documents HLA-identical twins with primary biliary cirrhosis, providing added evidence for a genetically determined abnormal immune response in this liver disorder, possibly to a specific viral or other environmental factor.http://dx.doi.org/10.1155/1994/954162
collection DOAJ
language English
format Article
sources DOAJ
author Hugh J Freeman
Robert J Bailey
spellingShingle Hugh J Freeman
Robert J Bailey
Primary Biliary Cirrhosis in HLA-Identical Twin Sisters
Canadian Journal of Gastroenterology
author_facet Hugh J Freeman
Robert J Bailey
author_sort Hugh J Freeman
title Primary Biliary Cirrhosis in HLA-Identical Twin Sisters
title_short Primary Biliary Cirrhosis in HLA-Identical Twin Sisters
title_full Primary Biliary Cirrhosis in HLA-Identical Twin Sisters
title_fullStr Primary Biliary Cirrhosis in HLA-Identical Twin Sisters
title_full_unstemmed Primary Biliary Cirrhosis in HLA-Identical Twin Sisters
title_sort primary biliary cirrhosis in hla-identical twin sisters
publisher Hindawi Limited
series Canadian Journal of Gastroenterology
issn 0835-7900
publishDate 1994-01-01
description Human leukocyte antigen (HLA)-identical twin sisters with chronic liver disease were evaluated. Both had a childhood history of transient jaundice suggestive of a possible infectious cause. Subsequent studies in both siblings at age 51 years revealed antimitochondrial antibody-positive primary biliary cirrhosis. This report documents HLA-identical twins with primary biliary cirrhosis, providing added evidence for a genetically determined abnormal immune response in this liver disorder, possibly to a specific viral or other environmental factor.
url http://dx.doi.org/10.1155/1994/954162
work_keys_str_mv AT hughjfreeman primarybiliarycirrhosisinhlaidenticaltwinsisters
AT robertjbailey primarybiliarycirrhosisinhlaidenticaltwinsisters
_version_ 1725677307298840576

Similar Items