Primary Biliary Cirrhosis in HLA-Identical Twin Sisters
Human leukocyte antigen (HLA)-identical twin sisters with chronic liver disease were evaluated. Both had a childhood history of transient jaundice suggestive of a possible infectious cause. Subsequent studies in both siblings at age 51 years revealed antimitochondrial antibody-positive primary bilia...
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1994-01-01
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Series: | Canadian Journal of Gastroenterology |
Online Access: | http://dx.doi.org/10.1155/1994/954162 |
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doaj-f6002cfdda314919b8198e81734414b32020-11-24T22:49:05ZengHindawi LimitedCanadian Journal of Gastroenterology0835-79001994-01-0182889110.1155/1994/954162Primary Biliary Cirrhosis in HLA-Identical Twin SistersHugh J Freeman0Robert J Bailey1Department of Medicine (Gastroenterology), University Hospital and University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Medicine (Gastroenterology), Royal Alexandra Hospital and University of Alberta, Edmonton, Alberta, CanadaHuman leukocyte antigen (HLA)-identical twin sisters with chronic liver disease were evaluated. Both had a childhood history of transient jaundice suggestive of a possible infectious cause. Subsequent studies in both siblings at age 51 years revealed antimitochondrial antibody-positive primary biliary cirrhosis. This report documents HLA-identical twins with primary biliary cirrhosis, providing added evidence for a genetically determined abnormal immune response in this liver disorder, possibly to a specific viral or other environmental factor.http://dx.doi.org/10.1155/1994/954162 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hugh J Freeman Robert J Bailey |
spellingShingle |
Hugh J Freeman Robert J Bailey Primary Biliary Cirrhosis in HLA-Identical Twin Sisters Canadian Journal of Gastroenterology |
author_facet |
Hugh J Freeman Robert J Bailey |
author_sort |
Hugh J Freeman |
title |
Primary Biliary Cirrhosis in HLA-Identical Twin Sisters |
title_short |
Primary Biliary Cirrhosis in HLA-Identical Twin Sisters |
title_full |
Primary Biliary Cirrhosis in HLA-Identical Twin Sisters |
title_fullStr |
Primary Biliary Cirrhosis in HLA-Identical Twin Sisters |
title_full_unstemmed |
Primary Biliary Cirrhosis in HLA-Identical Twin Sisters |
title_sort |
primary biliary cirrhosis in hla-identical twin sisters |
publisher |
Hindawi Limited |
series |
Canadian Journal of Gastroenterology |
issn |
0835-7900 |
publishDate |
1994-01-01 |
description |
Human leukocyte antigen (HLA)-identical twin sisters with chronic liver disease were evaluated. Both had a childhood history of transient jaundice suggestive of a possible infectious cause. Subsequent studies in both siblings at age 51 years revealed antimitochondrial antibody-positive primary biliary cirrhosis. This report documents HLA-identical twins with primary biliary cirrhosis, providing added evidence for a genetically determined abnormal immune response in this liver disorder, possibly to a specific viral or other environmental factor. |
url |
http://dx.doi.org/10.1155/1994/954162 |
work_keys_str_mv |
AT hughjfreeman primarybiliarycirrhosisinhlaidenticaltwinsisters AT robertjbailey primarybiliarycirrhosisinhlaidenticaltwinsisters |
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