Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis

Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis

Radiation-induced fibrosis (RIF) develops months to years after initial radiation exposure. RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant amounts of extracellular matrix proteins. One of the main drivers for developing RIF is reactive oxygen species (ROS)...

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Main Authors: Shashank Shrishrimal, Elizabeth A. Kosmacek, Rebecca E. Oberley-Deegan
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2019/4278658
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spelling doaj-f61138b804a8420cb3ca7608bb5ecb012020-11-25T00:47:37ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942019-01-01201910.1155/2019/42786584278658Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced FibrosisShashank Shrishrimal0Elizabeth A. Kosmacek1Rebecca E. Oberley-Deegan2Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USADepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USADepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USARadiation-induced fibrosis (RIF) develops months to years after initial radiation exposure. RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant amounts of extracellular matrix proteins. One of the main drivers for developing RIF is reactive oxygen species (ROS) generated immediately after radiation exposure. Generation of ROS is known to induce epigenetic changes and cause differentiation of fibroblasts to myofibroblasts. Several antioxidant compounds have been shown to prevent radiation-induced epigenetic changes and the development of RIF. Therefore, reviewing the ROS-linked epigenetic changes in irradiated fibroblast cells is essential to understand the development and prevention of RIF.http://dx.doi.org/10.1155/2019/4278658
collection DOAJ
language English
format Article
sources DOAJ
author Shashank Shrishrimal
Elizabeth A. Kosmacek
Rebecca E. Oberley-Deegan
spellingShingle Shashank Shrishrimal
Elizabeth A. Kosmacek
Rebecca E. Oberley-Deegan
Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis
Oxidative Medicine and Cellular Longevity
author_facet Shashank Shrishrimal
Elizabeth A. Kosmacek
Rebecca E. Oberley-Deegan
author_sort Shashank Shrishrimal
title Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis
title_short Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis
title_full Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis
title_fullStr Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis
title_full_unstemmed Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis
title_sort reactive oxygen species drive epigenetic changes in radiation-induced fibrosis
publisher Hindawi Limited
series Oxidative Medicine and Cellular Longevity
issn 1942-0900
1942-0994
publishDate 2019-01-01
description Radiation-induced fibrosis (RIF) develops months to years after initial radiation exposure. RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant amounts of extracellular matrix proteins. One of the main drivers for developing RIF is reactive oxygen species (ROS) generated immediately after radiation exposure. Generation of ROS is known to induce epigenetic changes and cause differentiation of fibroblasts to myofibroblasts. Several antioxidant compounds have been shown to prevent radiation-induced epigenetic changes and the development of RIF. Therefore, reviewing the ROS-linked epigenetic changes in irradiated fibroblast cells is essential to understand the development and prevention of RIF.
url http://dx.doi.org/10.1155/2019/4278658
work_keys_str_mv AT shashankshrishrimal reactiveoxygenspeciesdriveepigeneticchangesinradiationinducedfibrosis
AT elizabethakosmacek reactiveoxygenspeciesdriveepigeneticchangesinradiationinducedfibrosis
AT rebeccaeoberleydeegan reactiveoxygenspeciesdriveepigeneticchangesinradiationinducedfibrosis
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