Premature Coronary Artery Disease and Familial Hypercholesterolemia: Need for Early Diagnosis and Cascade Screening in the Indian Population
Cardiovascular disease (CVD) is the leading cause of death in India, accounting for 28% of mortality. The average age of onset of CVD is younger (below 55 years) among Indians than in other populations. This may be due to bad lifestyle, genetic factors, or both. Hypertension, smoking, diabetes, and...
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Online Access: | http://dx.doi.org/10.1155/2012/658526 |
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doaj-f61f5c1e0a1e4e15822dd1e3c61a45882020-11-24T22:02:06ZengHindawi LimitedCardiology Research and Practice2090-80162090-05972012-01-01201210.1155/2012/658526658526Premature Coronary Artery Disease and Familial Hypercholesterolemia: Need for Early Diagnosis and Cascade Screening in the Indian PopulationN. Setia0I. C. Verma1B. Khan2A. Arora3Center of Medical Genetics, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110060, IndiaCenter of Medical Genetics, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110060, IndiaAtlanta Vascular Research Foundation, Saint Joseph's Translational Research Institute, 13562 Habersham, Northlake, Atlanta, GA 30084, USAHyperlipidemia Prevention Clinic, Department of Cardiology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi 110060, IndiaCardiovascular disease (CVD) is the leading cause of death in India, accounting for 28% of mortality. The average age of onset of CVD is younger (below 55 years) among Indians than in other populations. This may be due to bad lifestyle, genetic factors, or both. Hypertension, smoking, diabetes, and physical inactivity have been identified as modifiable risk factors for heart disease. Hypercholesterolemia is the most common and treatable cause of heart disease. Genetic factors that lead to hypercholesterolemia have not been fully studied in India. Familial Hypercholesterolemia results from mutations in the LDL receptor, ApoB, PCSK9, and ApoE genes. There is an urgent need to screen subjects with premature CAD and their relatives in India for the presence of FH, identify the mutations that lead to high cholesterol, and carry out cascade screening in the at-risk relatives. Those harbouring mutations in the above genes can be treated to lower the cholesterol levels, prevent early CVD, and avoid death. A programme based on these lines has been initiated in Delhi.http://dx.doi.org/10.1155/2012/658526 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
N. Setia I. C. Verma B. Khan A. Arora |
spellingShingle |
N. Setia I. C. Verma B. Khan A. Arora Premature Coronary Artery Disease and Familial Hypercholesterolemia: Need for Early Diagnosis and Cascade Screening in the Indian Population Cardiology Research and Practice |
author_facet |
N. Setia I. C. Verma B. Khan A. Arora |
author_sort |
N. Setia |
title |
Premature Coronary Artery Disease and Familial Hypercholesterolemia: Need for Early Diagnosis and Cascade Screening in the Indian Population |
title_short |
Premature Coronary Artery Disease and Familial Hypercholesterolemia: Need for Early Diagnosis and Cascade Screening in the Indian Population |
title_full |
Premature Coronary Artery Disease and Familial Hypercholesterolemia: Need for Early Diagnosis and Cascade Screening in the Indian Population |
title_fullStr |
Premature Coronary Artery Disease and Familial Hypercholesterolemia: Need for Early Diagnosis and Cascade Screening in the Indian Population |
title_full_unstemmed |
Premature Coronary Artery Disease and Familial Hypercholesterolemia: Need for Early Diagnosis and Cascade Screening in the Indian Population |
title_sort |
premature coronary artery disease and familial hypercholesterolemia: need for early diagnosis and cascade screening in the indian population |
publisher |
Hindawi Limited |
series |
Cardiology Research and Practice |
issn |
2090-8016 2090-0597 |
publishDate |
2012-01-01 |
description |
Cardiovascular disease (CVD) is the leading cause of death in India, accounting for 28% of mortality. The average age of onset of CVD is younger (below 55 years) among Indians than in other populations. This may be due to bad lifestyle, genetic factors, or both. Hypertension, smoking, diabetes, and physical inactivity have been identified as modifiable risk factors for heart disease. Hypercholesterolemia is the most common and treatable cause of heart disease. Genetic factors that lead to hypercholesterolemia have not been fully studied in India. Familial Hypercholesterolemia results from mutations in the LDL receptor, ApoB, PCSK9, and ApoE genes. There is an urgent need to screen subjects with premature CAD and their relatives in India for the presence of FH, identify the mutations that lead to high cholesterol, and carry out cascade screening in the at-risk relatives. Those harbouring mutations in the above genes can be treated to lower the cholesterol levels, prevent early CVD, and avoid death. A programme based on these lines has been initiated in Delhi. |
url |
http://dx.doi.org/10.1155/2012/658526 |
work_keys_str_mv |
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