A Randomised Controlled Trial of the Efficacy and Safety of 0.25% Desoximetasone Cream (Topoxy) Compared with 0.25% Desoximetasone Cream (Topicorte) for the Treatment of Scalp Psoriasis

• Main Authors: Leena Chularojanamontri, Narumol Silpa-archa, Pichanee Chaweekulrat, Chayanee Likitwattananurak, Puncharas Weerasubpong, Natchaya Junsuwan, Norramon Charoenpipatsin, Chanisada Wongpraparut
• Format: Article
• Language: English
• Published: Mahidol University 2020-05-01
• Series: Siriraj Medical Journal
• Subjects: Desoximetasone cream; scalp psoriasis; topicorte; topoxy
• Online Access: https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/241932

Objective: To compare the efficacy and safety of a generic desoximetasone cream (Topoxy) with the reference form, Topicorte, for the treatment of scalp psoriasis. Methods: A randomised, double-blind, controlled study was conducted. Altogether, 105 patients with psoriasis lesions covering more than 10% of the scalp were randomised into three groups. The first, second and third groups received a placebo, Topoxy and Topicorte, respectively. The scalp psoriasis severities were assessed at weeks 0, 2, 4 and 8, using the Investigator Global Assessment (IGA) scale and Total Sign Score (TSS). The safety profiles of the products were assessed by the patients and physicians. Results: Topoxy and Topicorte were significantly more effective than the placebo in achieving at least a two-grade improvement in the IGA score from baseline at weeks 2, 4 and 8, and there were no significant differences between Topoxy and Topicorte. The TSS of both creams were significantly lower than that of the placebo at weeks 2, 4 and 8. All patients tolerated well to the therapy. Conclusion: Topoxy and Topicorte had comparable efficacies for scalp psoriasis., The medications were superior to the placebo in all parameters, and  had a good safety profile.