Phosphonamidates are the first phosphorus-based zinc binding motif to show inhibition of β-class carbonic anhydrases from bacteria, fungi, and protozoa
A primary strategy to combat antimicrobial resistance is the identification of novel therapeutic targets and anti-infectives with alternative mechanisms of action. The inhibition of the metalloenzymes carbonic anhydrases (CAs, EC 4.2.1.1) from pathogens (bacteria, fungi, and protozoa) was shown to p...
Main Authors: | Siham A. Alissa, Hanan A. Alghulikah, Zeid A. Alothman, Sameh M. Osman, Sonia Del Prete, Clemente Capasso, Alessio Nocentini, Claudiu T. Supuran |
---|---|
Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2020-01-01
|
Series: | Journal of Enzyme Inhibition and Medicinal Chemistry |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/14756366.2019.1681987 |
Similar Items
-
Synthesis of New Lipophilic Phosphonate and Phosphonamidate Analogues of N-Acetylmuramyl-L-alanyl-D-isoglutamine Related to LK 423
by: Uroš Urleb, et al.
Published: (2002-05-01) -
Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules
by: Thilo Focken, et al.
Published: (2014-08-01) -
An overview on the recently discovered iota-carbonic anhydrases
by: Alessio Nocentini, et al.
Published: (2021-01-01) -
Bacterial ι-carbonic anhydrase: a new active class of carbonic anhydrase identified in the genome of the Gram-negative bacterium Burkholderia territorii
by: Sonia Del Prete, et al.
Published: (2020-01-01) -
Solid-Phase Synthesis of Phosphorothioate/Phosphonothioate and Phosphoramidate/Phosphonamidate Oligonucleotides
by: Ondřej Kostov, et al.
Published: (2019-05-01)