Changes in Lactate Production, Lactate Dehydrogenase Genes Expression and DNA Methylation in Response to Tamoxifen Resistance Development in MCF-7 Cell Line

Changes in Lactate Production, Lactate Dehydrogenase Genes Expression and DNA Methylation in Response to Tamoxifen Resistance Development in MCF-7 Cell Line

Lactate dehydrogenase (LDH) is a key enzyme in the last step of glycolysis, playing a role in the pyruvate-to-lactate reaction. It is associated with the prognosis and metastasis of many cancers, including breast cancer. In this study, we investigated the changes in <i>LDH</i> gene expre...

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Bibliographic Details
Main Authors: Lama Hamadneh, Lara Al-Lakkis, Ala A. Alhusban, Shahd Tarawneh, Bashaer Abu-Irmaileh, Sokiyna Albustanji, Abdel Qader Al-Bawab
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Genes
Subjects:
<i>LDHB</i> hypomethylation
breast cancer
lactate
<i>LDHA</i> and <i>LDHB</i> gene expression
tamoxifen resistance
Online Access:https://www.mdpi.com/2073-4425/12/5/777

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