The role of dasatinib in the management of chronic myeloid leukemia
Runzhe Chen, Baoan Chen Department of Hematology and Oncology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province, People’s Republic of China Abstract: Dasatinib is a second-generation tyrosine kinase inhibitor...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Dove Medical Press
2015-02-01
|
Series: | Drug Design, Development and Therapy |
Online Access: | http://www.dovepress.com/the-role-of-dasatinib-in-the-management-ofnbspchronic-myeloid-leukemia-peer-reviewed-article-DDDT |
id |
doaj-f6350286c5624ae0836975b84159bd0f |
---|---|
record_format |
Article |
spelling |
doaj-f6350286c5624ae0836975b84159bd0f2020-11-24T20:54:53ZengDove Medical PressDrug Design, Development and Therapy1177-88812015-02-012015default77377920345The role of dasatinib in the management of chronic myeloid leukemiaChen RChen B Runzhe Chen, Baoan Chen Department of Hematology and Oncology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province, People’s Republic of China Abstract: Dasatinib is a second-generation tyrosine kinase inhibitor (TKI) for chronic, blastic, or accelerated phase chronic myeloid leukemia (CML) patients who are resistant or intolerant to previous treatment. It potently inhibits BCR/ABL and SRC-family kinases (SRC, LCK, HCK, YES, FYN, FGR, BLK, LYN, FRK), as well as c-KIT, PDGFR-a and -b, and ephrin receptor kinase. Various clinical trials have provided evidence that it has more durable complete hematologic and cytogenetic responses, as well as more potency in imatinib-resistant or -intolerant CML, and it has also shown its advantages in newly diagnosed CML compared to imatinib. In this review, we mainly focus on the structure, mechanisms, pharmacokinetics, and pharmacogenetics of dasatinib. We also summarize clinical trials with dasatinib on CML and provide our recommendations for dasatinib in the treatment of CML. Keywords: imatinib, tyrosine kinase inhibitor, clinical trials http://www.dovepress.com/the-role-of-dasatinib-in-the-management-ofnbspchronic-myeloid-leukemia-peer-reviewed-article-DDDT |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chen R Chen B |
spellingShingle |
Chen R Chen B The role of dasatinib in the management of chronic myeloid leukemia Drug Design, Development and Therapy |
author_facet |
Chen R Chen B |
author_sort |
Chen R |
title |
The role of dasatinib in the management of chronic myeloid leukemia |
title_short |
The role of dasatinib in the management of chronic myeloid leukemia |
title_full |
The role of dasatinib in the management of chronic myeloid leukemia |
title_fullStr |
The role of dasatinib in the management of chronic myeloid leukemia |
title_full_unstemmed |
The role of dasatinib in the management of chronic myeloid leukemia |
title_sort |
role of dasatinib in the management of chronic myeloid leukemia |
publisher |
Dove Medical Press |
series |
Drug Design, Development and Therapy |
issn |
1177-8881 |
publishDate |
2015-02-01 |
description |
Runzhe Chen, Baoan Chen Department of Hematology and Oncology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province, People’s Republic of China Abstract: Dasatinib is a second-generation tyrosine kinase inhibitor (TKI) for chronic, blastic, or accelerated phase chronic myeloid leukemia (CML) patients who are resistant or intolerant to previous treatment. It potently inhibits BCR/ABL and SRC-family kinases (SRC, LCK, HCK, YES, FYN, FGR, BLK, LYN, FRK), as well as c-KIT, PDGFR-a and -b, and ephrin receptor kinase. Various clinical trials have provided evidence that it has more durable complete hematologic and cytogenetic responses, as well as more potency in imatinib-resistant or -intolerant CML, and it has also shown its advantages in newly diagnosed CML compared to imatinib. In this review, we mainly focus on the structure, mechanisms, pharmacokinetics, and pharmacogenetics of dasatinib. We also summarize clinical trials with dasatinib on CML and provide our recommendations for dasatinib in the treatment of CML. Keywords: imatinib, tyrosine kinase inhibitor, clinical trials |
url |
http://www.dovepress.com/the-role-of-dasatinib-in-the-management-ofnbspchronic-myeloid-leukemia-peer-reviewed-article-DDDT |
work_keys_str_mv |
AT chenr theroleofdasatinibinthemanagementofnbspchronicmyeloidleukemia AT chenb theroleofdasatinibinthemanagementofnbspchronicmyeloidleukemia AT chenr roleofdasatinibinthemanagementofnbspchronicmyeloidleukemia AT chenb roleofdasatinibinthemanagementofnbspchronicmyeloidleukemia |
_version_ |
1716793423105622016 |