Effect of renal perfusion and structural heterogeneity on shear wave elastography of the kidney: an in vivo and ex vivo study
Abstract Background To evaluate the effect of perfusion status on elasticity measurements of different compartments in the kidney using shear wave elastography (SWE) both in vivo and ex vivo. Methods Thirty-two rabbit kidneys were used to observe the elasticity variation caused by renal artery steno...
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doaj-f635c04cec20405c92b1efccf8090b202020-11-25T02:16:44ZengBMCBMC Nephrology1471-23692017-08-0118111110.1186/s12882-017-0679-2Effect of renal perfusion and structural heterogeneity on shear wave elastography of the kidney: an in vivo and ex vivo studyXiaona Liu0Na Li1Tao Xu2Fang Sun3Rui Li4Qimin Gao5Lianxiang Chen6Chaoyang Wen7Chinese PLA (People’s Liberation Army) Medical SchoolChinese PLA (People’s Liberation Army) Medical SchoolDepartment of Ultrasound, Chinese PLA Navy General HospitalDepartment of Ultrasound, Binzhou Medical University HospitalDepartment of Ultrasound, Binzhou Medical University HospitalDepartment of Ultrasound, Binzhou Medical University HospitalDepartment of Ultrasound, Binzhou Medical University HospitalChinese PLA (People’s Liberation Army) Medical SchoolAbstract Background To evaluate the effect of perfusion status on elasticity measurements of different compartments in the kidney using shear wave elastography (SWE) both in vivo and ex vivo. Methods Thirty-two rabbit kidneys were used to observe the elasticity variation caused by renal artery stenosis and vein ligation in vivo, and six beagle kidneys were studied ex vivo to explore the effect of renal perfusion on elasticity. Supersonic SWE was applied to quantify the elasticity values of different renal compartments (cortex, medulla and sinus). Additionally, histopathological examination was performed to explore the possible mechanisms. Results The elasticity of the cortex was higher than that of the medulla, and the elasticity of the sinus was lowest among the compartments in native kidneys. The Young’s modulus (YM) of the cortex, medulla and sinus increased gradually as the duration of renal vein ligation increased, from 16.34 ± 1.01 kPa to 55.06 ± 5.61 kPa, 13.71 ± 1.16 kPa to 39.63 ± 2.91 kPa, and 12.61 ± 0.84 kPa to 29.30 ± 2.04 kPa, respectively. In contrast, the YM of the three compartments respectively decreased with progressive artery stenosis, from 16.34 ± 1.83 kPa to 11.21 ± 1.79 kPa, 13.31 ± 1.67 kPa to 8.07 ± 1.37 kPa, and 12.78 ± 2.66 kPa to 6.72 ± 0.95 kPa. Artery perfusion was the main factor influencing elasticity in ex vivo. The cortical elasticity was more prone to change with renal perfusion both in vivo and ex vivo. Histopathological examination showed progressive changes in the structure and content of the three compartments, consistent with the elasticity variation. Conclusions Both the complex structure/anisotropy and the perfusion of the kidney obviously influence the evaluation of renal elasticity. The measurement of SWE should be performed at a specific location along a certain angle or direction, and renal perfusion status should also be taken into account to ensure reproducible detection.http://link.springer.com/article/10.1186/s12882-017-0679-2Renal elasticityPerfusionShear wave elastographyYoung’s modulusAnisotropyHaemodynamics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiaona Liu Na Li Tao Xu Fang Sun Rui Li Qimin Gao Lianxiang Chen Chaoyang Wen |
spellingShingle |
Xiaona Liu Na Li Tao Xu Fang Sun Rui Li Qimin Gao Lianxiang Chen Chaoyang Wen Effect of renal perfusion and structural heterogeneity on shear wave elastography of the kidney: an in vivo and ex vivo study BMC Nephrology Renal elasticity Perfusion Shear wave elastography Young’s modulus Anisotropy Haemodynamics |
author_facet |
Xiaona Liu Na Li Tao Xu Fang Sun Rui Li Qimin Gao Lianxiang Chen Chaoyang Wen |
author_sort |
Xiaona Liu |
title |
Effect of renal perfusion and structural heterogeneity on shear wave elastography of the kidney: an in vivo and ex vivo study |
title_short |
Effect of renal perfusion and structural heterogeneity on shear wave elastography of the kidney: an in vivo and ex vivo study |
title_full |
Effect of renal perfusion and structural heterogeneity on shear wave elastography of the kidney: an in vivo and ex vivo study |
title_fullStr |
Effect of renal perfusion and structural heterogeneity on shear wave elastography of the kidney: an in vivo and ex vivo study |
title_full_unstemmed |
Effect of renal perfusion and structural heterogeneity on shear wave elastography of the kidney: an in vivo and ex vivo study |
title_sort |
effect of renal perfusion and structural heterogeneity on shear wave elastography of the kidney: an in vivo and ex vivo study |
publisher |
BMC |
series |
BMC Nephrology |
issn |
1471-2369 |
publishDate |
2017-08-01 |
description |
Abstract Background To evaluate the effect of perfusion status on elasticity measurements of different compartments in the kidney using shear wave elastography (SWE) both in vivo and ex vivo. Methods Thirty-two rabbit kidneys were used to observe the elasticity variation caused by renal artery stenosis and vein ligation in vivo, and six beagle kidneys were studied ex vivo to explore the effect of renal perfusion on elasticity. Supersonic SWE was applied to quantify the elasticity values of different renal compartments (cortex, medulla and sinus). Additionally, histopathological examination was performed to explore the possible mechanisms. Results The elasticity of the cortex was higher than that of the medulla, and the elasticity of the sinus was lowest among the compartments in native kidneys. The Young’s modulus (YM) of the cortex, medulla and sinus increased gradually as the duration of renal vein ligation increased, from 16.34 ± 1.01 kPa to 55.06 ± 5.61 kPa, 13.71 ± 1.16 kPa to 39.63 ± 2.91 kPa, and 12.61 ± 0.84 kPa to 29.30 ± 2.04 kPa, respectively. In contrast, the YM of the three compartments respectively decreased with progressive artery stenosis, from 16.34 ± 1.83 kPa to 11.21 ± 1.79 kPa, 13.31 ± 1.67 kPa to 8.07 ± 1.37 kPa, and 12.78 ± 2.66 kPa to 6.72 ± 0.95 kPa. Artery perfusion was the main factor influencing elasticity in ex vivo. The cortical elasticity was more prone to change with renal perfusion both in vivo and ex vivo. Histopathological examination showed progressive changes in the structure and content of the three compartments, consistent with the elasticity variation. Conclusions Both the complex structure/anisotropy and the perfusion of the kidney obviously influence the evaluation of renal elasticity. The measurement of SWE should be performed at a specific location along a certain angle or direction, and renal perfusion status should also be taken into account to ensure reproducible detection. |
topic |
Renal elasticity Perfusion Shear wave elastography Young’s modulus Anisotropy Haemodynamics |
url |
http://link.springer.com/article/10.1186/s12882-017-0679-2 |
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