A New Parasiticidal Compound in T. solium Cysticercosis
The effect of 16α-bromoepiandrosterone (EpiBr), a dehydroepiandrosterone (DHEA) analogue, was tested on the cysticerci of Taenia solium, both in vitro and in vivo. In vitro treatment of T. solium cultures with EpiBr reduced scolex evagination, growth, motility, and viability in dose- and time-depend...
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Hindawi Limited
2013-01-01
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| Series: | BioMed Research International |
| Online Access: | http://dx.doi.org/10.1155/2013/505240 |
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doaj-f63ffede4bd84e6dbf208d7cdf64fb2f2020-11-24T22:37:23ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/505240505240A New Parasiticidal Compound in T. solium CysticercosisRomel Hernández-Bello0Galileo Escobedo1Julio Cesar Carrero2Claudia Cervantes-Rebolledo3Charles Dowding4James Frincke5Chris Reading6Jorge Morales-Montor7Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, 04510 México, DF, MexicoUnidad de Medicina Experimental, Hospital General de México, 06726 México, DF, MexicoDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, 04510 México, DF, MexicoDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, 04510 México, DF, MexicoHollis-Eden Pharmaceuticals, Inc., San diego, CA 92121, USAHollis-Eden Pharmaceuticals, Inc., San diego, CA 92121, USAHollis-Eden Pharmaceuticals, Inc., San diego, CA 92121, USADepartamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, 04510 México, DF, MexicoThe effect of 16α-bromoepiandrosterone (EpiBr), a dehydroepiandrosterone (DHEA) analogue, was tested on the cysticerci of Taenia solium, both in vitro and in vivo. In vitro treatment of T. solium cultures with EpiBr reduced scolex evagination, growth, motility, and viability in dose- and time-dependent fashions. Administration of EpiBr prior to infection with T. solium cysticerci in hamsters reduced the number and size of developed taenias in the intestine, compared with controls. These effects were associated to an increase in splenocyte proliferation in infected hamsters. These results leave open the possibility of assessing the potential of this hormonal analogue as a possible antiparasite drug, particularly in cysticercosis and taeniosis.http://dx.doi.org/10.1155/2013/505240 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Romel Hernández-Bello Galileo Escobedo Julio Cesar Carrero Claudia Cervantes-Rebolledo Charles Dowding James Frincke Chris Reading Jorge Morales-Montor |
| spellingShingle |
Romel Hernández-Bello Galileo Escobedo Julio Cesar Carrero Claudia Cervantes-Rebolledo Charles Dowding James Frincke Chris Reading Jorge Morales-Montor A New Parasiticidal Compound in T. solium Cysticercosis BioMed Research International |
| author_facet |
Romel Hernández-Bello Galileo Escobedo Julio Cesar Carrero Claudia Cervantes-Rebolledo Charles Dowding James Frincke Chris Reading Jorge Morales-Montor |
| author_sort |
Romel Hernández-Bello |
| title |
A New Parasiticidal Compound in T. solium Cysticercosis |
| title_short |
A New Parasiticidal Compound in T. solium Cysticercosis |
| title_full |
A New Parasiticidal Compound in T. solium Cysticercosis |
| title_fullStr |
A New Parasiticidal Compound in T. solium Cysticercosis |
| title_full_unstemmed |
A New Parasiticidal Compound in T. solium Cysticercosis |
| title_sort |
new parasiticidal compound in t. solium cysticercosis |
| publisher |
Hindawi Limited |
| series |
BioMed Research International |
| issn |
2314-6133 2314-6141 |
| publishDate |
2013-01-01 |
| description |
The effect of 16α-bromoepiandrosterone (EpiBr), a dehydroepiandrosterone (DHEA) analogue, was tested on the cysticerci of Taenia solium, both in vitro and in vivo. In vitro treatment of T. solium cultures with EpiBr reduced scolex evagination, growth, motility, and viability in dose- and time-dependent fashions. Administration of EpiBr prior to infection with T. solium cysticerci in hamsters reduced the number and size of developed taenias in the intestine, compared with controls. These effects were associated to an increase in splenocyte proliferation in infected hamsters. These results leave open the possibility of assessing the potential of this hormonal analogue as a possible antiparasite drug, particularly in cysticercosis and taeniosis. |
| url |
http://dx.doi.org/10.1155/2013/505240 |
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