TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus.
TPL-2 (COT, MAP3K8) kinase activates the MEK1/2-ERK1/2 MAPK signaling pathway in innate immune responses following TLR, TNFR1 and IL-1R stimulation. TPL-2 contributes to type-1/Th17-mediated autoimmunity and control of intracellular pathogens. We recently demonstrated TPL-2 reduces severe airway all...
Main Authors: | Yashaswini Kannan, Lewis J Entwistle, Victoria S Pelly, Jimena Perez-Lloret, Alan W Walker, Steven C Ley, Mark S Wilson |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-07-01
|
Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC5560741?pdf=render |
Similar Items
-
The immunobiology of Heligmosomoides polygyrus in the murine host
by: Lawrence, Catherine Elizabeth
Published: (1990) -
Immunogenetics of Heligmosomoides polygyrus (Nematospiroides dubius) in mice
by: Wahid, Faisal Numman
Published: (1991) -
Determining the impact of Heligmosomoides polygyrus infection on the development of colitis
by: Katsandegwaza, Brunette
Published: (2020) -
The cellular basis of immune responses to Heligmosomoides polygyrus in the mouse
by: Parker, Susan J.
Published: (1988) -
Conjoint Heligmosomoides polygyrus and Trypanosoma congolense infection in mice
by: Fakae, Barinema Beke
Published: (1993)