Upregulation of surfactant synthesis triggers ABCA1-mediated basolateral phospholipid efflux

Upregulation of surfactant synthesis triggers ABCA1-mediated basolateral phospholipid efflux

Alveolar type II lung epithelia produce surfactant, an essential surface-active material highly enriched with disaturated phosphatidylcholine (DSPC), which requires a key regulatory enzyme, CTP:phosphocholine cytidylyltransferase α (CCTα), for its synthesis before its export apically into the alveol...

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Bibliographic Details
Main Authors: Jiming Zhou, Yong You, Alan J. Ryan, Rama K. Mallampalli
Format: Article
Language:English
Published: Elsevier 2004-09-01
Series:Journal of Lipid Research
Subjects:
CTP:phosphocholine cytidylyltransferase
phosphatidylcholine
ATP binding cassette transporter 1
human lung adenocarcinoma cell line
overexpression
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520312931

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