Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives

Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives

Abstract Background Pyrimidine is an important pharmacophore in the field of medicinal chemistry and exhibit a broad spectrum of biological potentials. A study was carried out to identify the target protein of potent bis-pyrimidine derivatives using reverse docking program. PharmMapper, a robust onl...

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Bibliographic Details
Main Authors: Sanjiv Kumar, Jagbir Singh, Balasubramanian Narasimhan, Syed Adnan Ali Shah, Siong Meng Lim, Kalavathy Ramasamy, Vasudevan Mani
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Chemistry Central Journal
Subjects:
PharmMapper
Bis-pyrimidine derivatives
GTPase HRas
Docking study
HEK-293
Online Access:http://link.springer.com/article/10.1186/s13065-018-0475-5

Internet

http://link.springer.com/article/10.1186/s13065-018-0475-5

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