Exercise training attenuates right ventricular remodeling in rats with pulmonary arterial stenosis
Introduction: Pulmonary arterial stenosis (PAS) is a congenital defect that causes outflow tract obstruction of the right ventricle (RV). Currently, negative issues are reported in the PAS management: not all patients may be eligible to surgeries; there is often the need for another surgery during p...
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doaj-f64cf1eb956b47e08a2d7fc92dc31f572020-11-25T00:15:31ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2016-12-01710.3389/fphys.2016.00541224553Exercise training attenuates right ventricular remodeling in rats with pulmonary arterial stenosisBrunno Lemes0Stella Souza Vieira1Stella Souza Vieira2Ednei Luiz Antonio3Luís Felipe Neves dos Santos4Leslie Andrews Portes5Regiane Santos Feliciano6Helenita Antonia Oliveira7Jose Antonio Silva8Paulo de Tarso Camillo de Carvalho9Paulo José Ferreira Tucci10Andrey Jorge Serra11Federal University of São PauloUninoveFederal University of São PauloFederal University of São PauloFederal University of São PauloFederal University of São PauloUninoveUninoveUninoveUninoveFederal University of São PauloUninoveIntroduction: Pulmonary arterial stenosis (PAS) is a congenital defect that causes outflow tract obstruction of the right ventricle (RV). Currently, negative issues are reported in the PAS management: not all patients may be eligible to surgeries; there is often the need for another surgery during passage to adulthood; patients with mild stenosis may have later cardiac adverse repercussions. Thus, the search for approaches to counteract the long-term PAS effects showed to be a current target. At the study herein, we evaluated the cardioprotective role of exercise training in rats submitted to PAS for 9 weeks. Methods & Results: Exercise resulted in improved physical fitness and systolic RV function. Exercise also blunted concentric cavity changes, diastolic dysfunction, and fibrosis induced by PAS. Exercise additional benefits were also reported in a pro-survival signal, in which there were increased Akt1 activity and normalized myocardial apoptosis. These findings were accompanied by microRNA-1 downregulation and microRNA-21 upregulation. Moreover, exercise was associated with a higher myocardial abundance of the sarcomeric protein α-MHC and proteins that modulate calcium handling - ryanodine receptor and Serca 2, supporting the potential role of exercise in improving myocardial performance. Conclusion: Our results represent the first demonstration that exercise can attenuate the RV remodeling in an experimental PAS. The cardioprotective effects were associated with positive modulation of RV function, survival signaling pathway, apoptosis, and proteins involved in the regulation of myocardial contractility.http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00541/fullcardiac hypertrophycardiac remodelingexercise trainingarterial pulmonary stenosisright ventricular hypertrophy. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Brunno Lemes Stella Souza Vieira Stella Souza Vieira Ednei Luiz Antonio Luís Felipe Neves dos Santos Leslie Andrews Portes Regiane Santos Feliciano Helenita Antonia Oliveira Jose Antonio Silva Paulo de Tarso Camillo de Carvalho Paulo José Ferreira Tucci Andrey Jorge Serra |
spellingShingle |
Brunno Lemes Stella Souza Vieira Stella Souza Vieira Ednei Luiz Antonio Luís Felipe Neves dos Santos Leslie Andrews Portes Regiane Santos Feliciano Helenita Antonia Oliveira Jose Antonio Silva Paulo de Tarso Camillo de Carvalho Paulo José Ferreira Tucci Andrey Jorge Serra Exercise training attenuates right ventricular remodeling in rats with pulmonary arterial stenosis Frontiers in Physiology cardiac hypertrophy cardiac remodeling exercise training arterial pulmonary stenosis right ventricular hypertrophy. |
author_facet |
Brunno Lemes Stella Souza Vieira Stella Souza Vieira Ednei Luiz Antonio Luís Felipe Neves dos Santos Leslie Andrews Portes Regiane Santos Feliciano Helenita Antonia Oliveira Jose Antonio Silva Paulo de Tarso Camillo de Carvalho Paulo José Ferreira Tucci Andrey Jorge Serra |
author_sort |
Brunno Lemes |
title |
Exercise training attenuates right ventricular remodeling in rats with pulmonary arterial stenosis |
title_short |
Exercise training attenuates right ventricular remodeling in rats with pulmonary arterial stenosis |
title_full |
Exercise training attenuates right ventricular remodeling in rats with pulmonary arterial stenosis |
title_fullStr |
Exercise training attenuates right ventricular remodeling in rats with pulmonary arterial stenosis |
title_full_unstemmed |
Exercise training attenuates right ventricular remodeling in rats with pulmonary arterial stenosis |
title_sort |
exercise training attenuates right ventricular remodeling in rats with pulmonary arterial stenosis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2016-12-01 |
description |
Introduction: Pulmonary arterial stenosis (PAS) is a congenital defect that causes outflow tract obstruction of the right ventricle (RV). Currently, negative issues are reported in the PAS management: not all patients may be eligible to surgeries; there is often the need for another surgery during passage to adulthood; patients with mild stenosis may have later cardiac adverse repercussions. Thus, the search for approaches to counteract the long-term PAS effects showed to be a current target. At the study herein, we evaluated the cardioprotective role of exercise training in rats submitted to PAS for 9 weeks. Methods & Results: Exercise resulted in improved physical fitness and systolic RV function. Exercise also blunted concentric cavity changes, diastolic dysfunction, and fibrosis induced by PAS. Exercise additional benefits were also reported in a pro-survival signal, in which there were increased Akt1 activity and normalized myocardial apoptosis. These findings were accompanied by microRNA-1 downregulation and microRNA-21 upregulation. Moreover, exercise was associated with a higher myocardial abundance of the sarcomeric protein α-MHC and proteins that modulate calcium handling - ryanodine receptor and Serca 2, supporting the potential role of exercise in improving myocardial performance. Conclusion: Our results represent the first demonstration that exercise can attenuate the RV remodeling in an experimental PAS. The cardioprotective effects were associated with positive modulation of RV function, survival signaling pathway, apoptosis, and proteins involved in the regulation of myocardial contractility. |
topic |
cardiac hypertrophy cardiac remodeling exercise training arterial pulmonary stenosis right ventricular hypertrophy. |
url |
http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00541/full |
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