Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia
Similar to bile duct cancer or cholangiocarcinoma (CCA) in the western world, opisthorchiasis-associated CCA in Southeast Asia is an aggressive cancer with high mortality rates. It is known to cause a significant health burden in the opisthorchiasis region in Thailand and possibly throughout mainlan...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fmed.2018.00117/full |
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English |
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Article |
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DOAJ |
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Narong Khuntikeo Narong Khuntikeo Attapol Titapun Attapol Titapun Watcharin Loilome Watcharin Loilome Puangrat Yongvanit Puangrat Yongvanit Bandit Thinkhamrop Bandit Thinkhamrop Nittaya Chamadol Nittaya Chamadol Thidarat Boonmars Thidarat Boonmars Teerachai Nethanomsak Teerachai Nethanomsak Ross H. Andrews Ross H. Andrews Trevor N. Petney Trevor N. Petney Paiboon Sithithaworn Paiboon Sithithaworn |
| spellingShingle |
Narong Khuntikeo Narong Khuntikeo Attapol Titapun Attapol Titapun Watcharin Loilome Watcharin Loilome Puangrat Yongvanit Puangrat Yongvanit Bandit Thinkhamrop Bandit Thinkhamrop Nittaya Chamadol Nittaya Chamadol Thidarat Boonmars Thidarat Boonmars Teerachai Nethanomsak Teerachai Nethanomsak Ross H. Andrews Ross H. Andrews Trevor N. Petney Trevor N. Petney Paiboon Sithithaworn Paiboon Sithithaworn Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia Frontiers in Medicine Opisthorchis viverrini cholangiocarcinoma screening primary prevention secondary prevention tertiary care program |
| author_facet |
Narong Khuntikeo Narong Khuntikeo Attapol Titapun Attapol Titapun Watcharin Loilome Watcharin Loilome Puangrat Yongvanit Puangrat Yongvanit Bandit Thinkhamrop Bandit Thinkhamrop Nittaya Chamadol Nittaya Chamadol Thidarat Boonmars Thidarat Boonmars Teerachai Nethanomsak Teerachai Nethanomsak Ross H. Andrews Ross H. Andrews Trevor N. Petney Trevor N. Petney Paiboon Sithithaworn Paiboon Sithithaworn |
| author_sort |
Narong Khuntikeo |
| title |
Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia |
| title_short |
Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia |
| title_full |
Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia |
| title_fullStr |
Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia |
| title_full_unstemmed |
Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia |
| title_sort |
current perspectives on opisthorchiasis control and cholangiocarcinoma detection in southeast asia |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Medicine |
| issn |
2296-858X |
| publishDate |
2018-04-01 |
| description |
Similar to bile duct cancer or cholangiocarcinoma (CCA) in the western world, opisthorchiasis-associated CCA in Southeast Asia is an aggressive cancer with high mortality rates. It is known to cause a significant health burden in the opisthorchiasis region in Thailand and possibly throughout mainland Southeast. To reduce this health burden, a comprehensive prevention and control program for opisthorchiasis, as well as CCA, is required. In this review, our aim is to provide a brief update of the current situation regarding the natural history of opisthorchiasis and health burden of CCA in Southeast Asia. A comprehensive approach to tackling these issues being implemented in Thailand under the “Cholangiocarcinoma Screening and Care Program” is described. This comprehensive program consists of a three stage prevention and patient care program. The primary prevention component involves opisthorchiasis screening using a new and sensitive urine assay. The secondary prevention component involves screening for CCA and periductal fibrosis, with suspected CCA patients following the protocol for confirmation and appropriate treatment. Due to the eco-epidemiology of opisthorchiasis-induced CCA, the anticipated impacts and outcomes of the program include short-, medium-, and the long-term goals for the reduction of CCA incidence. To achieve long-term sustainable impacts, concerted efforts to raise social awareness and participating action by general public, non-government organizations, and government agencies are necessary. The strategic plans developed for this program can be expanded for use in other endemic areas as well as being a model for use in other chronic diseases. |
| topic |
Opisthorchis viverrini cholangiocarcinoma screening primary prevention secondary prevention tertiary care program |
| url |
http://journal.frontiersin.org/article/10.3389/fmed.2018.00117/full |
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doaj-f64ddc1e917b43d38b56f2488107d3ca2020-11-25T00:15:31ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2018-04-01510.3389/fmed.2018.00117364147Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast AsiaNarong Khuntikeo0Narong Khuntikeo1Attapol Titapun2Attapol Titapun3Watcharin Loilome4Watcharin Loilome5Puangrat Yongvanit6Puangrat Yongvanit7Bandit Thinkhamrop8Bandit Thinkhamrop9Nittaya Chamadol10Nittaya Chamadol11Thidarat Boonmars12Thidarat Boonmars13Teerachai Nethanomsak14Teerachai Nethanomsak15Ross H. Andrews16Ross H. Andrews17Trevor N. Petney18Trevor N. Petney19Paiboon Sithithaworn20Paiboon Sithithaworn21Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Foundation, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandCurriculum and Instruction Program, Faculty of Education, Khon Kaen University, Khon Kaen, ThailandCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandFaculty of Medicine, St Mary’s Campus, Imperial College, London, United KingdomCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand0Department of Ecology and Parasitology, Institute of Zoology, Karlsruhe Institute of Technology, Karlsruhe, GermanyCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, ThailandDepartment of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, ThailandSimilar to bile duct cancer or cholangiocarcinoma (CCA) in the western world, opisthorchiasis-associated CCA in Southeast Asia is an aggressive cancer with high mortality rates. It is known to cause a significant health burden in the opisthorchiasis region in Thailand and possibly throughout mainland Southeast. To reduce this health burden, a comprehensive prevention and control program for opisthorchiasis, as well as CCA, is required. In this review, our aim is to provide a brief update of the current situation regarding the natural history of opisthorchiasis and health burden of CCA in Southeast Asia. A comprehensive approach to tackling these issues being implemented in Thailand under the “Cholangiocarcinoma Screening and Care Program” is described. This comprehensive program consists of a three stage prevention and patient care program. The primary prevention component involves opisthorchiasis screening using a new and sensitive urine assay. The secondary prevention component involves screening for CCA and periductal fibrosis, with suspected CCA patients following the protocol for confirmation and appropriate treatment. Due to the eco-epidemiology of opisthorchiasis-induced CCA, the anticipated impacts and outcomes of the program include short-, medium-, and the long-term goals for the reduction of CCA incidence. To achieve long-term sustainable impacts, concerted efforts to raise social awareness and participating action by general public, non-government organizations, and government agencies are necessary. The strategic plans developed for this program can be expanded for use in other endemic areas as well as being a model for use in other chronic diseases.http://journal.frontiersin.org/article/10.3389/fmed.2018.00117/fullOpisthorchis viverrinicholangiocarcinomascreeningprimary preventionsecondary preventiontertiary care program |