Task-Evoked Negative BOLD Response in the Default Mode Network Does Not Alter Its Functional Connectivity
While functional connectivity networks are often extracted from resting-state fMRI scans, they have been shown to be active during task performance as well. However, the effect of an in-scanner task on functional connectivity networks is not completely understood. While there is evidence that task-e...
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doaj-f64eb53ed4964b98888088807c664a172020-11-25T02:47:07ZengFrontiers Media S.A.Frontiers in Computational Neuroscience1662-51882018-08-011210.3389/fncom.2018.00067373943Task-Evoked Negative BOLD Response in the Default Mode Network Does Not Alter Its Functional ConnectivityQolamreza R. Razlighi0Qolamreza R. Razlighi1Qolamreza R. Razlighi2Department of Neurology, Collage of Physician and Surgeons, Columbia University, New York, NY, United StatesTaub Institute for Research on Alzheimer's Disease and The Aging, Columbia University, New York, NY, United StatesBiomedical Engineering Department, Columbia University, New York, NY, United StatesWhile functional connectivity networks are often extracted from resting-state fMRI scans, they have been shown to be active during task performance as well. However, the effect of an in-scanner task on functional connectivity networks is not completely understood. While there is evidence that task-evoked positive BOLD response can alter functional connectivity networks, particularly in the primary sensorimotor cortices, the effect of task-evoked negative BOLD response on the functional connectivity of the Default mode network (DMN) is somewhat ambiguous. In this study, we aim to investigate whether task performance, which is associated with negative BOLD response in the DMN regions, alters the time-course of functional connectivity in the same regions obtained by independent component analysis (ICA). ICA has been used to effectively extract functional connectivity networks during task performance and resting-state. We first demonstrate that performing a simple visual-motor task alters the temporal time-course of the network extracted from the primary visual cortex. Then we show that despite detecting a robust task-evoked negative BOLD response in the DMN regions, a simple visual-motor task does not alter the functional connectivity of the DMN regions. Our findings suggest that different mechanisms may underlie the relationship between task-related activation/deactivation networks and the overlapping functional connectivity networks in the human large-scale brain networks.https://www.frontiersin.org/article/10.3389/fncom.2018.00067/fullnegative BOLD responsefunctional connectivityDefault mode network (DMN)visual networktask-evoked activityfMRI BOLD |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qolamreza R. Razlighi Qolamreza R. Razlighi Qolamreza R. Razlighi |
spellingShingle |
Qolamreza R. Razlighi Qolamreza R. Razlighi Qolamreza R. Razlighi Task-Evoked Negative BOLD Response in the Default Mode Network Does Not Alter Its Functional Connectivity Frontiers in Computational Neuroscience negative BOLD response functional connectivity Default mode network (DMN) visual network task-evoked activity fMRI BOLD |
author_facet |
Qolamreza R. Razlighi Qolamreza R. Razlighi Qolamreza R. Razlighi |
author_sort |
Qolamreza R. Razlighi |
title |
Task-Evoked Negative BOLD Response in the Default Mode Network Does Not Alter Its Functional Connectivity |
title_short |
Task-Evoked Negative BOLD Response in the Default Mode Network Does Not Alter Its Functional Connectivity |
title_full |
Task-Evoked Negative BOLD Response in the Default Mode Network Does Not Alter Its Functional Connectivity |
title_fullStr |
Task-Evoked Negative BOLD Response in the Default Mode Network Does Not Alter Its Functional Connectivity |
title_full_unstemmed |
Task-Evoked Negative BOLD Response in the Default Mode Network Does Not Alter Its Functional Connectivity |
title_sort |
task-evoked negative bold response in the default mode network does not alter its functional connectivity |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Computational Neuroscience |
issn |
1662-5188 |
publishDate |
2018-08-01 |
description |
While functional connectivity networks are often extracted from resting-state fMRI scans, they have been shown to be active during task performance as well. However, the effect of an in-scanner task on functional connectivity networks is not completely understood. While there is evidence that task-evoked positive BOLD response can alter functional connectivity networks, particularly in the primary sensorimotor cortices, the effect of task-evoked negative BOLD response on the functional connectivity of the Default mode network (DMN) is somewhat ambiguous. In this study, we aim to investigate whether task performance, which is associated with negative BOLD response in the DMN regions, alters the time-course of functional connectivity in the same regions obtained by independent component analysis (ICA). ICA has been used to effectively extract functional connectivity networks during task performance and resting-state. We first demonstrate that performing a simple visual-motor task alters the temporal time-course of the network extracted from the primary visual cortex. Then we show that despite detecting a robust task-evoked negative BOLD response in the DMN regions, a simple visual-motor task does not alter the functional connectivity of the DMN regions. Our findings suggest that different mechanisms may underlie the relationship between task-related activation/deactivation networks and the overlapping functional connectivity networks in the human large-scale brain networks. |
topic |
negative BOLD response functional connectivity Default mode network (DMN) visual network task-evoked activity fMRI BOLD |
url |
https://www.frontiersin.org/article/10.3389/fncom.2018.00067/full |
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