Statin Treatment Induced a Lipogenic Expression Hierarchical Network Centered by SREBF2 in the Liver
Statin treatment is a major prevention treatment for hypercholesterolemia and the management of patients with increased risk of cardiovascular disease (CVD) due to its protective effects. However, its long-term safety was questioned regarding its potential role in new-onset type 2 diabetes mellitus,...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-07-01
|
Series: | Frontiers in Endocrinology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.573824/full |
id |
doaj-f6531b5c59e84a81ad7366affd231c53 |
---|---|
record_format |
Article |
spelling |
doaj-f6531b5c59e84a81ad7366affd231c532021-07-19T10:13:28ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-07-011210.3389/fendo.2021.573824573824Statin Treatment Induced a Lipogenic Expression Hierarchical Network Centered by SREBF2 in the LiverShiyu Song0Mengyuan Niu1Qiao Liang2Lei Wang3Haiyan Min4Yuming Peng5Hongwei Wang6Hongwei Wang7Qian Gao8Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, ChinaCenter for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, ChinaCenter for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, ChinaCenter for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, ChinaCenter for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, ChinaDepartment of General Practice of Central Hospital of Karamay, Karamay, ChinaCenter for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, ChinaState Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing, ChinaCenter for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, ChinaStatin treatment is a major prevention treatment for hypercholesterolemia and the management of patients with increased risk of cardiovascular disease (CVD) due to its protective effects. However, its long-term safety was questioned regarding its potential role in new-onset type 2 diabetes mellitus, and its effect on gene regulation in the liver is not yet fully understood. By reanalyzing the transcriptome of the livers of patients with obesity and hypercholesterolemia, this study shows a multiple module organization that is related to various clinical metabolic parameters and identified an expression hierarchical network involving cholesterol and fatty acid syntheses in the liver of statin-treated patients. The key genes of the network were validated by QPCR in the hepatocytes upon statin treatment. The upregulation of the key enzymes involving the synthesis of Acetyl-CoA and the induction of gentle global acetylation of pan-protein and histone H4 in hepatocytes were observed. The study provides an overall view of the statin effect on transcriptional and post-transcriptional regulation of genes in the liver.https://www.frontiersin.org/articles/10.3389/fendo.2021.573824/fullstatinliverprotein acetylationWGCNAobesitydiabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shiyu Song Mengyuan Niu Qiao Liang Lei Wang Haiyan Min Yuming Peng Hongwei Wang Hongwei Wang Qian Gao |
spellingShingle |
Shiyu Song Mengyuan Niu Qiao Liang Lei Wang Haiyan Min Yuming Peng Hongwei Wang Hongwei Wang Qian Gao Statin Treatment Induced a Lipogenic Expression Hierarchical Network Centered by SREBF2 in the Liver Frontiers in Endocrinology statin liver protein acetylation WGCNA obesity diabetes |
author_facet |
Shiyu Song Mengyuan Niu Qiao Liang Lei Wang Haiyan Min Yuming Peng Hongwei Wang Hongwei Wang Qian Gao |
author_sort |
Shiyu Song |
title |
Statin Treatment Induced a Lipogenic Expression Hierarchical Network Centered by SREBF2 in the Liver |
title_short |
Statin Treatment Induced a Lipogenic Expression Hierarchical Network Centered by SREBF2 in the Liver |
title_full |
Statin Treatment Induced a Lipogenic Expression Hierarchical Network Centered by SREBF2 in the Liver |
title_fullStr |
Statin Treatment Induced a Lipogenic Expression Hierarchical Network Centered by SREBF2 in the Liver |
title_full_unstemmed |
Statin Treatment Induced a Lipogenic Expression Hierarchical Network Centered by SREBF2 in the Liver |
title_sort |
statin treatment induced a lipogenic expression hierarchical network centered by srebf2 in the liver |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2021-07-01 |
description |
Statin treatment is a major prevention treatment for hypercholesterolemia and the management of patients with increased risk of cardiovascular disease (CVD) due to its protective effects. However, its long-term safety was questioned regarding its potential role in new-onset type 2 diabetes mellitus, and its effect on gene regulation in the liver is not yet fully understood. By reanalyzing the transcriptome of the livers of patients with obesity and hypercholesterolemia, this study shows a multiple module organization that is related to various clinical metabolic parameters and identified an expression hierarchical network involving cholesterol and fatty acid syntheses in the liver of statin-treated patients. The key genes of the network were validated by QPCR in the hepatocytes upon statin treatment. The upregulation of the key enzymes involving the synthesis of Acetyl-CoA and the induction of gentle global acetylation of pan-protein and histone H4 in hepatocytes were observed. The study provides an overall view of the statin effect on transcriptional and post-transcriptional regulation of genes in the liver. |
topic |
statin liver protein acetylation WGCNA obesity diabetes |
url |
https://www.frontiersin.org/articles/10.3389/fendo.2021.573824/full |
work_keys_str_mv |
AT shiyusong statintreatmentinducedalipogenicexpressionhierarchicalnetworkcenteredbysrebf2intheliver AT mengyuanniu statintreatmentinducedalipogenicexpressionhierarchicalnetworkcenteredbysrebf2intheliver AT qiaoliang statintreatmentinducedalipogenicexpressionhierarchicalnetworkcenteredbysrebf2intheliver AT leiwang statintreatmentinducedalipogenicexpressionhierarchicalnetworkcenteredbysrebf2intheliver AT haiyanmin statintreatmentinducedalipogenicexpressionhierarchicalnetworkcenteredbysrebf2intheliver AT yumingpeng statintreatmentinducedalipogenicexpressionhierarchicalnetworkcenteredbysrebf2intheliver AT hongweiwang statintreatmentinducedalipogenicexpressionhierarchicalnetworkcenteredbysrebf2intheliver AT hongweiwang statintreatmentinducedalipogenicexpressionhierarchicalnetworkcenteredbysrebf2intheliver AT qiangao statintreatmentinducedalipogenicexpressionhierarchicalnetworkcenteredbysrebf2intheliver |
_version_ |
1721295158421487616 |