Serum alphaJadrenomodulating activity in arterial hypertension
In experiments with longitudinal stripes of cow renal artery, serum taken from healthy people and patients with Stage II arterial hypertension (AH), in titrations 1:100, 1:500, 1:1000, and 1:10000, did not influence tonotropic, alpha-drenoreceptor (AR) activating effect of adrenaline (10–6 g/ml). In...
Main Authors: | , , , |
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Format: | Article |
Language: | Russian |
Published: |
«FIRMA «SILICEA» LLC
2008-02-01
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Series: | Российский кардиологический журнал |
Subjects: | |
Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1530 |
Summary: | In experiments with longitudinal stripes of cow renal artery, serum taken from healthy people and patients with Stage II arterial hypertension (AH), in titrations 1:100, 1:500, 1:1000, and 1:10000, did not influence tonotropic, alpha-drenoreceptor (AR) activating effect of adrenaline (10–6 g/ml). In titration 1:50, this effect was enhanced, due to serum alpha-adrenosensitizing activity. In Stage III AH, female serum did not affect tonotropic effect of adrenaline, and male serum reduced it in titrations 1:50, 1:100, and 1:1000, due to alpha-adrenoblocking activity. Therefore, 1) serum of cormotensive people and patients with Stage II AH could contain endogenous sensitizer of alpha-AR (ESAAR), and in Stage III AH its level might be reduced; 2) serum of males with Stage III AH could contain endogenous blocker of alpha?AR (EBAAR). The nature of ASAAR and EBAAR and their role in AH pathogenesis is discussed. |
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ISSN: | 1560-4071 2618-7620 |