Serum alphaJadrenomodulating activity in arterial hypertension

• Main Authors: N. L. Demina, V. I. Tsirkin, E. I. Tarlovskaya, A. A. Kostyaev
• Format: Article
• Language: Russian
• Published: «FIRMA «SILICEA» LLC 2008-02-01
• Series: Российский кардиологический журнал
• Subjects: endogenous modulators; modulators of alphajadrenoreactivity; arterial hypertension; experimental study
• Online Access: https://russjcardiol.elpub.ru/jour/article/view/1530
• ISSN: 1560-4071; 2618-7620

In experiments with longitudinal stripes of cow renal artery, serum taken from healthy people and patients with Stage II arterial hypertension (AH), in titrations 1:100, 1:500, 1:1000, and 1:10000, did not influence tonotropic, alpha-drenoreceptor (AR) activating effect of adrenaline (10–6 g/ml). In titration 1:50, this effect was enhanced, due to serum alpha-adrenosensitizing activity. In Stage III AH, female serum did not affect tonotropic effect of adrenaline, and male serum reduced it in titrations 1:50, 1:100, and 1:1000, due to alpha-adrenoblocking activity. Therefore, 1) serum of cormotensive people and patients with Stage II AH could contain endogenous sensitizer of alpha-AR (ESAAR), and in Stage III AH its level might be reduced; 2) serum of males with Stage III AH could contain endogenous blocker of alpha?AR (EBAAR). The nature of ASAAR and EBAAR and their role in AH pathogenesis is discussed.