PTEN inhibits BMI1 function independently of its phosphatase activity

PTEN inhibits BMI1 function independently of its phosphatase activity

<p>Abstract</p> <p>Background</p> <p><it>PTEN </it>is the second most mutated tumor suppressor gene other than p53. It suppresses tumorigenesis by dephosphorylating phosphatidylinositol (3,4,5)-triphosphate (<b>PIP3</b>) to phosphatidylinositol (...

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Bibliographic Details
Main Authors: Kapoor Anil, He Lizhi, Fan Catherine, Rybak Adrian P, De Melo Jason, Cutz Jean-Claude, Tang Damu
Format: Article
Language:English
Published: BMC 2009-11-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/8/1/98

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