Dissecting the Role of Subtypes of Gastrointestinal Vagal Afferents

Dissecting the Role of Subtypes of Gastrointestinal Vagal Afferents

Gastrointestinal (GI) vagal afferents convey sensory signals from the GI tract to the brain. Numerous subtypes of GI vagal afferent have been identified but their individual roles in gut function and feeding regulation are unclear. In the past decade, technical approaches to selectively target vagal...

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Bibliographic Details
Main Authors: Yoko B. Wang, Guillaume de Lartigue, Amanda J. Page
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Physiology
Subjects:
gastrointestinal tract
vagal afferent subtypes
gut brain axis
molecular tools
feeding behaviour
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00643/full
Description
Summary:Gastrointestinal (GI) vagal afferents convey sensory signals from the GI tract to the brain. Numerous subtypes of GI vagal afferent have been identified but their individual roles in gut function and feeding regulation are unclear. In the past decade, technical approaches to selectively target vagal afferent subtypes and to assess their function has significantly progressed. This review examines the classification of GI vagal afferent subtypes and discusses the current available techniques to study vagal afferents. Investigating the distribution of GI vagal afferent subtypes and understanding how to access and modulate individual populations are essential to dissect their fundamental roles in the gut-brain axis.
ISSN:1664-042X

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