High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural Ecuador

Leptospira spp., which comprise 3 clusters (pathogenic, saprophytic, and intermediate) that vary in pathogenicity, infect >1 million persons worldwide each year. The disease burden of the intermediate leptospires is unclear. To increase knowledge of this cluster, we used new molecular approaches...

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Main Authors: Jorge Chiriboga, Verónica Barragan, Gabriela Arroyo, Andrea Sosa, Dawn N. Birdsell, Karool España, Ana Mora, Emilia Espín, María Eugenia Mejía, Melba Morales, Carmina Pinargote, Manuel Gonzalez, Rudy Hartskeerl, Paul Keim, Gustavo Bretas, Joseph N.S. Eisenberg, Gabriel Trueba
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2015-12-01
Series:Emerging Infectious Diseases
Subjects:
Online Access:https://wwwnc.cdc.gov/eid/article/21/12/14-0659_article
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spelling doaj-f681383e718c46618e05e9d12bb911052020-11-25T00:26:00ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592015-12-0121122141214710.3201/eid2112.140659High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural EcuadorJorge ChiribogaVerónica BarraganGabriela ArroyoAndrea SosaDawn N. BirdsellKarool EspañaAna MoraEmilia EspínMaría Eugenia MejíaMelba MoralesCarmina PinargoteManuel GonzalezRudy HartskeerlPaul KeimGustavo BretasJoseph N.S. EisenbergGabriel TruebaLeptospira spp., which comprise 3 clusters (pathogenic, saprophytic, and intermediate) that vary in pathogenicity, infect >1 million persons worldwide each year. The disease burden of the intermediate leptospires is unclear. To increase knowledge of this cluster, we used new molecular approaches to characterize Leptospira spp. in 464 samples from febrile patients in rural, semiurban, and urban communities in Ecuador; in 20 samples from nonfebrile persons in the rural community; and in 206 samples from animals in the semiurban community. We observed a higher percentage of leptospiral DNA–positive samples from febrile persons in rural (64%) versus urban (21%) and semiurban (25%) communities; no leptospires were detected in nonfebrile persons. The percentage of intermediate cluster strains in humans (96%) was higher than that of pathogenic cluster strains (4%); strains in animal samples belonged to intermediate (49%) and pathogenic (51%) clusters. Intermediate cluster strains may be causing a substantial amount of fever in coastal Ecuador.https://wwwnc.cdc.gov/eid/article/21/12/14-0659_articleLeptospira spp.Ecuadorintermediate clusterintermediate speciesfevercarrier animals
collection DOAJ
language English
format Article
sources DOAJ
author Jorge Chiriboga
Verónica Barragan
Gabriela Arroyo
Andrea Sosa
Dawn N. Birdsell
Karool España
Ana Mora
Emilia Espín
María Eugenia Mejía
Melba Morales
Carmina Pinargote
Manuel Gonzalez
Rudy Hartskeerl
Paul Keim
Gustavo Bretas
Joseph N.S. Eisenberg
Gabriel Trueba
spellingShingle Jorge Chiriboga
Verónica Barragan
Gabriela Arroyo
Andrea Sosa
Dawn N. Birdsell
Karool España
Ana Mora
Emilia Espín
María Eugenia Mejía
Melba Morales
Carmina Pinargote
Manuel Gonzalez
Rudy Hartskeerl
Paul Keim
Gustavo Bretas
Joseph N.S. Eisenberg
Gabriel Trueba
High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural Ecuador
Emerging Infectious Diseases
Leptospira spp.
Ecuador
intermediate cluster
intermediate species
fever
carrier animals
author_facet Jorge Chiriboga
Verónica Barragan
Gabriela Arroyo
Andrea Sosa
Dawn N. Birdsell
Karool España
Ana Mora
Emilia Espín
María Eugenia Mejía
Melba Morales
Carmina Pinargote
Manuel Gonzalez
Rudy Hartskeerl
Paul Keim
Gustavo Bretas
Joseph N.S. Eisenberg
Gabriel Trueba
author_sort Jorge Chiriboga
title High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural Ecuador
title_short High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural Ecuador
title_full High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural Ecuador
title_fullStr High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural Ecuador
title_full_unstemmed High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural Ecuador
title_sort high prevalence of intermediate leptospira spp. dna in febrile humans from urban and rural ecuador
publisher Centers for Disease Control and Prevention
series Emerging Infectious Diseases
issn 1080-6040
1080-6059
publishDate 2015-12-01
description Leptospira spp., which comprise 3 clusters (pathogenic, saprophytic, and intermediate) that vary in pathogenicity, infect >1 million persons worldwide each year. The disease burden of the intermediate leptospires is unclear. To increase knowledge of this cluster, we used new molecular approaches to characterize Leptospira spp. in 464 samples from febrile patients in rural, semiurban, and urban communities in Ecuador; in 20 samples from nonfebrile persons in the rural community; and in 206 samples from animals in the semiurban community. We observed a higher percentage of leptospiral DNA–positive samples from febrile persons in rural (64%) versus urban (21%) and semiurban (25%) communities; no leptospires were detected in nonfebrile persons. The percentage of intermediate cluster strains in humans (96%) was higher than that of pathogenic cluster strains (4%); strains in animal samples belonged to intermediate (49%) and pathogenic (51%) clusters. Intermediate cluster strains may be causing a substantial amount of fever in coastal Ecuador.
topic Leptospira spp.
Ecuador
intermediate cluster
intermediate species
fever
carrier animals
url https://wwwnc.cdc.gov/eid/article/21/12/14-0659_article
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