High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural Ecuador
Leptospira spp., which comprise 3 clusters (pathogenic, saprophytic, and intermediate) that vary in pathogenicity, infect >1 million persons worldwide each year. The disease burden of the intermediate leptospires is unclear. To increase knowledge of this cluster, we used new molecular approaches...
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Centers for Disease Control and Prevention
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doaj-f681383e718c46618e05e9d12bb911052020-11-25T00:26:00ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592015-12-0121122141214710.3201/eid2112.140659High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural EcuadorJorge ChiribogaVerónica BarraganGabriela ArroyoAndrea SosaDawn N. BirdsellKarool EspañaAna MoraEmilia EspínMaría Eugenia MejíaMelba MoralesCarmina PinargoteManuel GonzalezRudy HartskeerlPaul KeimGustavo BretasJoseph N.S. EisenbergGabriel TruebaLeptospira spp., which comprise 3 clusters (pathogenic, saprophytic, and intermediate) that vary in pathogenicity, infect >1 million persons worldwide each year. The disease burden of the intermediate leptospires is unclear. To increase knowledge of this cluster, we used new molecular approaches to characterize Leptospira spp. in 464 samples from febrile patients in rural, semiurban, and urban communities in Ecuador; in 20 samples from nonfebrile persons in the rural community; and in 206 samples from animals in the semiurban community. We observed a higher percentage of leptospiral DNA–positive samples from febrile persons in rural (64%) versus urban (21%) and semiurban (25%) communities; no leptospires were detected in nonfebrile persons. The percentage of intermediate cluster strains in humans (96%) was higher than that of pathogenic cluster strains (4%); strains in animal samples belonged to intermediate (49%) and pathogenic (51%) clusters. Intermediate cluster strains may be causing a substantial amount of fever in coastal Ecuador.https://wwwnc.cdc.gov/eid/article/21/12/14-0659_articleLeptospira spp.Ecuadorintermediate clusterintermediate speciesfevercarrier animals |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jorge Chiriboga Verónica Barragan Gabriela Arroyo Andrea Sosa Dawn N. Birdsell Karool España Ana Mora Emilia Espín María Eugenia Mejía Melba Morales Carmina Pinargote Manuel Gonzalez Rudy Hartskeerl Paul Keim Gustavo Bretas Joseph N.S. Eisenberg Gabriel Trueba |
spellingShingle |
Jorge Chiriboga Verónica Barragan Gabriela Arroyo Andrea Sosa Dawn N. Birdsell Karool España Ana Mora Emilia Espín María Eugenia Mejía Melba Morales Carmina Pinargote Manuel Gonzalez Rudy Hartskeerl Paul Keim Gustavo Bretas Joseph N.S. Eisenberg Gabriel Trueba High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural Ecuador Emerging Infectious Diseases Leptospira spp. Ecuador intermediate cluster intermediate species fever carrier animals |
author_facet |
Jorge Chiriboga Verónica Barragan Gabriela Arroyo Andrea Sosa Dawn N. Birdsell Karool España Ana Mora Emilia Espín María Eugenia Mejía Melba Morales Carmina Pinargote Manuel Gonzalez Rudy Hartskeerl Paul Keim Gustavo Bretas Joseph N.S. Eisenberg Gabriel Trueba |
author_sort |
Jorge Chiriboga |
title |
High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural Ecuador |
title_short |
High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural Ecuador |
title_full |
High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural Ecuador |
title_fullStr |
High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural Ecuador |
title_full_unstemmed |
High Prevalence of Intermediate Leptospira spp. DNA in Febrile Humans from Urban and Rural Ecuador |
title_sort |
high prevalence of intermediate leptospira spp. dna in febrile humans from urban and rural ecuador |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2015-12-01 |
description |
Leptospira spp., which comprise 3 clusters (pathogenic, saprophytic, and intermediate) that vary in pathogenicity, infect >1 million persons worldwide each year. The disease burden of the intermediate leptospires is unclear. To increase knowledge of this cluster, we used new molecular approaches to characterize Leptospira spp. in 464 samples from febrile patients in rural, semiurban, and urban communities in Ecuador; in 20 samples from nonfebrile persons in the rural community; and in 206 samples from animals in the semiurban community. We observed a higher percentage of leptospiral DNA–positive samples from febrile persons in rural (64%) versus urban (21%) and semiurban (25%) communities; no leptospires were detected in nonfebrile persons. The percentage of intermediate cluster strains in humans (96%) was higher than that of pathogenic cluster strains (4%); strains in animal samples belonged to intermediate (49%) and pathogenic (51%) clusters. Intermediate cluster strains may be causing a substantial amount of fever in coastal Ecuador. |
topic |
Leptospira spp. Ecuador intermediate cluster intermediate species fever carrier animals |
url |
https://wwwnc.cdc.gov/eid/article/21/12/14-0659_article |
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