Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications

Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications

Summary: Bacillus Calmette-Guerin (BCG) vaccinations improve glycemic control in juvenile-onset Type I diabetes (T1D), an effect driven by restored sugar transport through aerobic glycolysis. In a pilot clinical trial, T1D, but not latent autoimmune diabetes of adults (LADA), exhibited lower blood s...

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Main Authors: Gabriella F. Shpilsky, Hiroyuki Takahashi, Anna Aristarkhova, Michele Weil, Nathan Ng, Kacie J. Nelson, Amanda Lee, Hui Zheng, Willem M. Kühtreiber, Denise L. Faustman
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:iScience
Subjects:
Human metabolism
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221011184
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spelling doaj-f68b0fbb675945938c37cc4f571f30ef2021-10-07T04:26:34ZengElsevieriScience2589-00422021-10-012410103150Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applicationsGabriella F. Shpilsky0Hiroyuki Takahashi1Anna Aristarkhova2Michele Weil3Nathan Ng4Kacie J. Nelson5Amanda Lee6Hui Zheng7Willem M. Kühtreiber8Denise L. Faustman9Massachusetts General Hospital, Immunobiology Laboratories, Boston, MA 02129, USAMassachusetts General Hospital, Immunobiology Laboratories, Boston, MA 02129, USAMassachusetts General Hospital, Immunobiology Laboratories, Boston, MA 02129, USAMassachusetts General Hospital, Diabetes Unit, Boston, MA 02129, USAMassachusetts General Hospital, Immunobiology Laboratories, Boston, MA 02129, USAMassachusetts General Hospital, Immunobiology Laboratories, Boston, MA 02129, USAMassachusetts General Hospital, Immunobiology Laboratories, Boston, MA 02129, USAMassachusetts General Hospital and Harvard Medical School, Statistics Department, Boston, MA 02129, USAMassachusetts General Hospital, Immunobiology Laboratories, Boston, MA 02129, USA; Massachusetts General Hospital and Harvard Medical School, Immunobiology Laboratories, Boston, MA 02129, USAMassachusetts General Hospital, Immunobiology Laboratories, Boston, MA 02129, USA; Massachusetts General Hospital and Harvard Medical School, Immunobiology Laboratories, Boston, MA 02129, USA; Corresponding authorSummary: Bacillus Calmette-Guerin (BCG) vaccinations improve glycemic control in juvenile-onset Type I diabetes (T1D), an effect driven by restored sugar transport through aerobic glycolysis. In a pilot clinical trial, T1D, but not latent autoimmune diabetes of adults (LADA), exhibited lower blood sugars after multidose BCG. Using a glucose transport assay, monocytes from T1D subjects showed a large stimulation index with BCG exposures; LADA subjects showed minimal BCG-induced sugar responsiveness. Monocytes from T1D, type 2 diabetes (T2D), and non-diabetic controls (NDC) were all responsive in vitro to BCG by augmented sugar utilization. Adults with prior neonatal BCG vaccination show accelerated glucose transport decades later. Finally, in vivo experiments with the NOD mouse (a T1D model) and obese db/db mice (a T2D model) confirm BCG's blood-sugar-lowering and accelerated glucose metabolism with sufficient dosing. Our results suggest that BCG's benefits for glucose metabolism may be broadly applicable to T1D and T2D, but less to LADA.http://www.sciencedirect.com/science/article/pii/S2589004221011184Human metabolismImmunology
collection DOAJ
language English
format Article
sources DOAJ
author Gabriella F. Shpilsky
Hiroyuki Takahashi
Anna Aristarkhova
Michele Weil
Nathan Ng
Kacie J. Nelson
Amanda Lee
Hui Zheng
Willem M. Kühtreiber
Denise L. Faustman
spellingShingle Gabriella F. Shpilsky
Hiroyuki Takahashi
Anna Aristarkhova
Michele Weil
Nathan Ng
Kacie J. Nelson
Amanda Lee
Hui Zheng
Willem M. Kühtreiber
Denise L. Faustman
Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications
iScience
Human metabolism
Immunology
author_facet Gabriella F. Shpilsky
Hiroyuki Takahashi
Anna Aristarkhova
Michele Weil
Nathan Ng
Kacie J. Nelson
Amanda Lee
Hui Zheng
Willem M. Kühtreiber
Denise L. Faustman
author_sort Gabriella F. Shpilsky
title Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications
title_short Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications
title_full Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications
title_fullStr Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications
title_full_unstemmed Bacillus Calmette-Guerin 's beneficial impact on glucose metabolism: evidence for broad based applications
title_sort bacillus calmette-guerin 's beneficial impact on glucose metabolism: evidence for broad based applications
publisher Elsevier
series iScience
issn 2589-0042
publishDate 2021-10-01
description Summary: Bacillus Calmette-Guerin (BCG) vaccinations improve glycemic control in juvenile-onset Type I diabetes (T1D), an effect driven by restored sugar transport through aerobic glycolysis. In a pilot clinical trial, T1D, but not latent autoimmune diabetes of adults (LADA), exhibited lower blood sugars after multidose BCG. Using a glucose transport assay, monocytes from T1D subjects showed a large stimulation index with BCG exposures; LADA subjects showed minimal BCG-induced sugar responsiveness. Monocytes from T1D, type 2 diabetes (T2D), and non-diabetic controls (NDC) were all responsive in vitro to BCG by augmented sugar utilization. Adults with prior neonatal BCG vaccination show accelerated glucose transport decades later. Finally, in vivo experiments with the NOD mouse (a T1D model) and obese db/db mice (a T2D model) confirm BCG's blood-sugar-lowering and accelerated glucose metabolism with sufficient dosing. Our results suggest that BCG's benefits for glucose metabolism may be broadly applicable to T1D and T2D, but less to LADA.
topic Human metabolism
Immunology
url http://www.sciencedirect.com/science/article/pii/S2589004221011184
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