A transomic cohort as a reference point for promoting a healthy human gut microbiome
More than a decade of gut microbiome studies have a common goal of improving human health. However, while most of the disease studies have focused on the elderly or the middle-aged, a reference cohort for the gut microbiome in young individuals has been lacking. It is also not clear what other omics...
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Elsevier
2021-06-01
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Series: | Medicine in Microecology |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2590097821000070 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhuye Jie Suisha Liang Qiuxia Ding Fei Li Shanmei Tang Dan Wang Yuxiang Lin Peishan Chen Kaiye Cai Xuemei Qiu Qiang Li Yunli Liao Dongsheng Zhou Heng Lian Yong Zuo Xiaomin Chen Weiqiao Rao Yan Ren Yuan Wang Jin Zi Rong Wang Hongcheng Zhou Haorong Lu Xiaohan Wang Wei Zhang Tao Zhang Liang Xiao Yang Zong Weibin Liu Huanming Yang Jian Wang Yong Hou Xiao Liu Karsten Kristiansen Huanzi Zhong Huijue Jia Xun Xu |
spellingShingle |
Zhuye Jie Suisha Liang Qiuxia Ding Fei Li Shanmei Tang Dan Wang Yuxiang Lin Peishan Chen Kaiye Cai Xuemei Qiu Qiang Li Yunli Liao Dongsheng Zhou Heng Lian Yong Zuo Xiaomin Chen Weiqiao Rao Yan Ren Yuan Wang Jin Zi Rong Wang Hongcheng Zhou Haorong Lu Xiaohan Wang Wei Zhang Tao Zhang Liang Xiao Yang Zong Weibin Liu Huanming Yang Jian Wang Yong Hou Xiao Liu Karsten Kristiansen Huanzi Zhong Huijue Jia Xun Xu A transomic cohort as a reference point for promoting a healthy human gut microbiome Medicine in Microecology |
author_facet |
Zhuye Jie Suisha Liang Qiuxia Ding Fei Li Shanmei Tang Dan Wang Yuxiang Lin Peishan Chen Kaiye Cai Xuemei Qiu Qiang Li Yunli Liao Dongsheng Zhou Heng Lian Yong Zuo Xiaomin Chen Weiqiao Rao Yan Ren Yuan Wang Jin Zi Rong Wang Hongcheng Zhou Haorong Lu Xiaohan Wang Wei Zhang Tao Zhang Liang Xiao Yang Zong Weibin Liu Huanming Yang Jian Wang Yong Hou Xiao Liu Karsten Kristiansen Huanzi Zhong Huijue Jia Xun Xu |
author_sort |
Zhuye Jie |
title |
A transomic cohort as a reference point for promoting a healthy human gut microbiome |
title_short |
A transomic cohort as a reference point for promoting a healthy human gut microbiome |
title_full |
A transomic cohort as a reference point for promoting a healthy human gut microbiome |
title_fullStr |
A transomic cohort as a reference point for promoting a healthy human gut microbiome |
title_full_unstemmed |
A transomic cohort as a reference point for promoting a healthy human gut microbiome |
title_sort |
transomic cohort as a reference point for promoting a healthy human gut microbiome |
publisher |
Elsevier |
series |
Medicine in Microecology |
issn |
2590-0978 |
publishDate |
2021-06-01 |
description |
More than a decade of gut microbiome studies have a common goal of improving human health. However, while most of the disease studies have focused on the elderly or the middle-aged, a reference cohort for the gut microbiome in young individuals has been lacking. It is also not clear what other omics data need to be measured to better understand the gut microbiome. Here, we present a cohort including 2183 adults with high-depth metagenomic shotgun sequencing data for the fecal microbiome and other omics data. In this multiomic cohort, we observe a number of vitamins, hormones, amino acids, and trace elements that correlated with the gut microbiome. Many of the associations are validated in an additional cohort consisting of 1404 individuals. Our comprehensive data are poised to provide advice to future populations and mechanistic study designs to better understand and manage our gut microbiome. |
url |
http://www.sciencedirect.com/science/article/pii/S2590097821000070 |
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doaj-f69927cada324410af1582646b68c12b2021-09-19T04:59:13ZengElsevierMedicine in Microecology2590-09782021-06-018100039A transomic cohort as a reference point for promoting a healthy human gut microbiomeZhuye Jie0Suisha Liang1Qiuxia Ding2Fei Li3Shanmei Tang4Dan Wang5Yuxiang Lin6Peishan Chen7Kaiye Cai8Xuemei Qiu9Qiang Li10Yunli Liao11Dongsheng Zhou12Heng Lian13Yong Zuo14Xiaomin Chen15Weiqiao Rao16Yan Ren17Yuan Wang18Jin Zi19Rong Wang20Hongcheng Zhou21Haorong Lu22Xiaohan Wang23Wei Zhang24Tao Zhang25Liang Xiao26Yang Zong27Weibin Liu28Huanming Yang29Jian Wang30Yong Hou31Xiao Liu32Karsten Kristiansen33Huanzi Zhong34Huijue Jia35Xun Xu36BGI-Shenzhen, Shenzhen, China; Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research, BGI-Shenzhen, Shenzhen, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen, Denmark; Corresponding author. Building 11, Beishan Industrial Zone, Yantian District, Shenzhen, 518083, China.BGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaChina National Genebank, BGI-Shenzhen, Shenzhen, 518120, ChinaChina National Genebank, BGI-Shenzhen, Shenzhen, 518120, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen, DenmarkBGI-Shenzhen, Shenzhen, China; Shenzhen Engineering Laboratory of Detection and Intervention of Human Intestinal Microbiome, BGI-Shenzhen, Shenzhen, China; BGI-Qingdao, BGI-Shenzhen, Qingdao, 266555, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, China; James D. Watson Institute of Genome Sciences, Hangzhou, ChinaBGI-Shenzhen, Shenzhen, China; James D. Watson Institute of Genome Sciences, Hangzhou, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen, Denmark; BGI-Qingdao, BGI-Shenzhen, Qingdao, 266555, ChinaBGI-Shenzhen, Shenzhen, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen, DenmarkBGI-Shenzhen, Shenzhen, China; Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research, BGI-Shenzhen, Shenzhen, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen, Denmark; Corresponding author. Building 11, Beishan Industrial Zone, Yantian District, Shenzhen, 518083, China.BGI-Shenzhen, Shenzhen, China; Corresponding author.More than a decade of gut microbiome studies have a common goal of improving human health. However, while most of the disease studies have focused on the elderly or the middle-aged, a reference cohort for the gut microbiome in young individuals has been lacking. It is also not clear what other omics data need to be measured to better understand the gut microbiome. Here, we present a cohort including 2183 adults with high-depth metagenomic shotgun sequencing data for the fecal microbiome and other omics data. In this multiomic cohort, we observe a number of vitamins, hormones, amino acids, and trace elements that correlated with the gut microbiome. Many of the associations are validated in an additional cohort consisting of 1404 individuals. Our comprehensive data are poised to provide advice to future populations and mechanistic study designs to better understand and manage our gut microbiome.http://www.sciencedirect.com/science/article/pii/S2590097821000070 |