A transomic cohort as a reference point for promoting a healthy human gut microbiome

• Main Authors: Zhuye Jie, Suisha Liang, Qiuxia Ding, Fei Li, Shanmei Tang, Dan Wang, Yuxiang Lin, Peishan Chen, Kaiye Cai, Xuemei Qiu, Qiang Li, Yunli Liao, Dongsheng Zhou, Heng Lian, Yong Zuo, Xiaomin Chen, Weiqiao Rao, Yan Ren, Yuan Wang, Jin Zi, Rong Wang, Hongcheng Zhou, Haorong Lu, Xiaohan Wang, Wei Zhang, Tao Zhang, Liang Xiao, Yang Zong, Weibin Liu, Huanming Yang, Jian Wang, Yong Hou, Xiao Liu, Karsten Kristiansen, Huanzi Zhong, Huijue Jia, Xun Xu
• Format: Article
• Language: English
• Published: Elsevier 2021-06-01
• Series: Medicine in Microecology
• Online Access: http://www.sciencedirect.com/science/article/pii/S2590097821000070

More than a decade of gut microbiome studies have a common goal of improving human health. However, while most of the disease studies have focused on the elderly or the middle-aged, a reference cohort for the gut microbiome in young individuals has been lacking. It is also not clear what other omics data need to be measured to better understand the gut microbiome. Here, we present a cohort including 2183 adults with high-depth metagenomic shotgun sequencing data for the fecal microbiome and other omics data. In this multiomic cohort, we observe a number of vitamins, hormones, amino acids, and trace elements that correlated with the gut microbiome. Many of the associations are validated in an additional cohort consisting of 1404 individuals. Our comprehensive data are poised to provide advice to future populations and mechanistic study designs to better understand and manage our gut microbiome.