Polyphenols as a Diet Therapy Concept for Endometriosis—Current Opinion and Future Perspectives
Endometriosis represents an often painful, estrogen-dependent gynecological disorder, defined by the existence of endometrial glands and stroma exterior to the uterine cavity. The disease provides a wide range of symptoms and affects women’s quality of life and reproductive functions. Despite resear...
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doaj-f69aae56d79140c795311dd3f606f8982021-04-18T23:00:35ZengMDPI AGNutrients2072-66432021-04-01131347134710.3390/nu13041347Polyphenols as a Diet Therapy Concept for Endometriosis—Current Opinion and Future PerspectivesAgata Gołąbek0Katarzyna Kowalska1Anna Olejnik2Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, 48 Wojska Polskiego St., 60-627 Poznan, PolandDepartment of Biotechnology and Food Microbiology, Poznan University of Life Sciences, 48 Wojska Polskiego St., 60-627 Poznan, PolandDepartment of Biotechnology and Food Microbiology, Poznan University of Life Sciences, 48 Wojska Polskiego St., 60-627 Poznan, PolandEndometriosis represents an often painful, estrogen-dependent gynecological disorder, defined by the existence of endometrial glands and stroma exterior to the uterine cavity. The disease provides a wide range of symptoms and affects women’s quality of life and reproductive functions. Despite research efforts and extensive investigations, this disease’s pathogenesis and molecular basis remain unclear. Conventional endometriosis treatment implies surgical resection, hormonal therapies, and treatment with nonsteroidal anti-inflammatory drugs, but their efficacy is currently limited due to many side effects. Therefore, exploring complementary and alternative therapy strategies, minimizing the current treatments’ adverse effects, is needed. Plants are sources of bioactive compounds that demonstrate broad-spectrum health-promoting effects and interact with molecular targets associated with endometriosis, such as cell proliferation, apoptosis, invasiveness, inflammation, oxidative stress, and angiogenesis. Anti-endometriotic properties are exhibited mainly by polyphenols, which can exert a potent phytoestrogen effect, modulating estrogen activity. The available evidence derived from preclinical research and several clinical studies indicates that natural biologically active compounds represent promising candidates for developing novel strategies in endometriosis management. The purpose of this review is to provide a comprehensive overview of polyphenols and their properties valuable for natural treatment strategy by interacting with different cellular and molecular targets involved in endometriosis progression.https://www.mdpi.com/2072-6643/13/4/1347endometriosisdiet therapypolyphenolsmolecular targetsapoptosisinvasion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Agata Gołąbek Katarzyna Kowalska Anna Olejnik |
spellingShingle |
Agata Gołąbek Katarzyna Kowalska Anna Olejnik Polyphenols as a Diet Therapy Concept for Endometriosis—Current Opinion and Future Perspectives Nutrients endometriosis diet therapy polyphenols molecular targets apoptosis invasion |
author_facet |
Agata Gołąbek Katarzyna Kowalska Anna Olejnik |
author_sort |
Agata Gołąbek |
title |
Polyphenols as a Diet Therapy Concept for Endometriosis—Current Opinion and Future Perspectives |
title_short |
Polyphenols as a Diet Therapy Concept for Endometriosis—Current Opinion and Future Perspectives |
title_full |
Polyphenols as a Diet Therapy Concept for Endometriosis—Current Opinion and Future Perspectives |
title_fullStr |
Polyphenols as a Diet Therapy Concept for Endometriosis—Current Opinion and Future Perspectives |
title_full_unstemmed |
Polyphenols as a Diet Therapy Concept for Endometriosis—Current Opinion and Future Perspectives |
title_sort |
polyphenols as a diet therapy concept for endometriosis—current opinion and future perspectives |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-04-01 |
description |
Endometriosis represents an often painful, estrogen-dependent gynecological disorder, defined by the existence of endometrial glands and stroma exterior to the uterine cavity. The disease provides a wide range of symptoms and affects women’s quality of life and reproductive functions. Despite research efforts and extensive investigations, this disease’s pathogenesis and molecular basis remain unclear. Conventional endometriosis treatment implies surgical resection, hormonal therapies, and treatment with nonsteroidal anti-inflammatory drugs, but their efficacy is currently limited due to many side effects. Therefore, exploring complementary and alternative therapy strategies, minimizing the current treatments’ adverse effects, is needed. Plants are sources of bioactive compounds that demonstrate broad-spectrum health-promoting effects and interact with molecular targets associated with endometriosis, such as cell proliferation, apoptosis, invasiveness, inflammation, oxidative stress, and angiogenesis. Anti-endometriotic properties are exhibited mainly by polyphenols, which can exert a potent phytoestrogen effect, modulating estrogen activity. The available evidence derived from preclinical research and several clinical studies indicates that natural biologically active compounds represent promising candidates for developing novel strategies in endometriosis management. The purpose of this review is to provide a comprehensive overview of polyphenols and their properties valuable for natural treatment strategy by interacting with different cellular and molecular targets involved in endometriosis progression. |
topic |
endometriosis diet therapy polyphenols molecular targets apoptosis invasion |
url |
https://www.mdpi.com/2072-6643/13/4/1347 |
work_keys_str_mv |
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