ACTN3 Gene and Susceptibility to Sarcopenia and Osteoporotic Status in Older Korean Adults
Background. Little information is available about molecular markers for sarcopenia and osteoporosis in Asian populations. Objective. This study investigated the association of the ACTN3 polymorphism with sarcopenia and osteoporotic status in older Korean adults. Methods. Older Korean 62 men and 270...
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Online Access: | http://dx.doi.org/10.1155/2017/4239648 |
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doaj-f69f45c82f75467d86d57d1daa01e23c2020-11-24T22:51:54ZengHindawi LimitedBioMed Research International2314-61332314-61412017-01-01201710.1155/2017/42396484239648ACTN3 Gene and Susceptibility to Sarcopenia and Osteoporotic Status in Older Korean AdultsJinkyung Cho0Inhwan Lee1Hyunsik Kang2College of Sport Science, Sungkyunkwan University, Suwon, Republic of KoreaCollege of Sport Science, Sungkyunkwan University, Suwon, Republic of KoreaCollege of Sport Science, Sungkyunkwan University, Suwon, Republic of KoreaBackground. Little information is available about molecular markers for sarcopenia and osteoporosis in Asian populations. Objective. This study investigated the association of the ACTN3 polymorphism with sarcopenia and osteoporotic status in older Korean adults. Methods. Older Korean 62 men and 270 women (mean age 73.7 ± 6.6 years) participated in this study. Body mass index, percent body fatness, appendicular skeletal muscle mass, and bone mineral density of the lumbar spine, femur, and total body were analyzed with dual-energy X-ray absorptiometry. ACTN3 R/X genotyping was determined using TaqMan probes. Results. Determination of odds ratios (ORs) and 95% confidence intervals (CIs) using binary logistic regression analyses showed that XX homozygotes were at a significantly higher risk of sarcopenia (OR=2.056, 95% CI=1.024–4.127, p=0.043) and osteoporosis (OR=2.794, 95% CI=1.208–5.461, p=0.016) than RR homozygotes (reference group, OR=1). The OR of XX homozygotes for having sarcopenia remained significant (OR=2.237, 95% CI=1.044–4.836, p=0.038) after adjustments for age, gender, body fatness, and serum vitamin D. The OR of XX homozygotes for having osteoporosis was no longer significant (OR=2.682, 95% CI=0.960–7.942, p=0.075) after adjustments for the covariates. Conclusion. Our findings suggest that the ACTN3 R577X genotype may influence decline in muscle and bone health phenotypes in older Korean adults.http://dx.doi.org/10.1155/2017/4239648 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jinkyung Cho Inhwan Lee Hyunsik Kang |
spellingShingle |
Jinkyung Cho Inhwan Lee Hyunsik Kang ACTN3 Gene and Susceptibility to Sarcopenia and Osteoporotic Status in Older Korean Adults BioMed Research International |
author_facet |
Jinkyung Cho Inhwan Lee Hyunsik Kang |
author_sort |
Jinkyung Cho |
title |
ACTN3 Gene and Susceptibility to Sarcopenia and Osteoporotic Status in Older Korean Adults |
title_short |
ACTN3 Gene and Susceptibility to Sarcopenia and Osteoporotic Status in Older Korean Adults |
title_full |
ACTN3 Gene and Susceptibility to Sarcopenia and Osteoporotic Status in Older Korean Adults |
title_fullStr |
ACTN3 Gene and Susceptibility to Sarcopenia and Osteoporotic Status in Older Korean Adults |
title_full_unstemmed |
ACTN3 Gene and Susceptibility to Sarcopenia and Osteoporotic Status in Older Korean Adults |
title_sort |
actn3 gene and susceptibility to sarcopenia and osteoporotic status in older korean adults |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2017-01-01 |
description |
Background. Little information is available about molecular markers for sarcopenia and osteoporosis in Asian populations. Objective. This study investigated the association of the ACTN3 polymorphism with sarcopenia and osteoporotic status in older Korean adults. Methods. Older Korean 62 men and 270 women (mean age 73.7 ± 6.6 years) participated in this study. Body mass index, percent body fatness, appendicular skeletal muscle mass, and bone mineral density of the lumbar spine, femur, and total body were analyzed with dual-energy X-ray absorptiometry. ACTN3 R/X genotyping was determined using TaqMan probes. Results. Determination of odds ratios (ORs) and 95% confidence intervals (CIs) using binary logistic regression analyses showed that XX homozygotes were at a significantly higher risk of sarcopenia (OR=2.056, 95% CI=1.024–4.127, p=0.043) and osteoporosis (OR=2.794, 95% CI=1.208–5.461, p=0.016) than RR homozygotes (reference group, OR=1). The OR of XX homozygotes for having sarcopenia remained significant (OR=2.237, 95% CI=1.044–4.836, p=0.038) after adjustments for age, gender, body fatness, and serum vitamin D. The OR of XX homozygotes for having osteoporosis was no longer significant (OR=2.682, 95% CI=0.960–7.942, p=0.075) after adjustments for the covariates. Conclusion. Our findings suggest that the ACTN3 R577X genotype may influence decline in muscle and bone health phenotypes in older Korean adults. |
url |
http://dx.doi.org/10.1155/2017/4239648 |
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