A yeast-based assay identifies drugs that interfere with immune evasion of the Epstein-Barr virus

A yeast-based assay identifies drugs that interfere with immune evasion of the Epstein-Barr virus

Epstein-Barr virus (EBV) is tightly associated with certain human cancers, but there is as yet no specific treatment against EBV-related diseases. The EBV-encoded EBNA1 protein is essential to maintain viral episomes and for viral persistence. As such, EBNA1 is expressed in all EBV-infected cells, a...

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Bibliographic Details
Main Authors: Cécile Voisset, Chrysoula Daskalogianni, Marie-Astrid Contesse, Anne Mazars, Hratch Arbach, Marie Le Cann, Flavie Soubigou, Sébastien Apcher, Robin Fåhraeus, Marc Blondel
Format: Article
Language:English
Published: The Company of Biologists 2014-04-01
Series:Disease Models & Mechanisms
Subjects:
EBV-associated cancers
Cell-based drug screening
EBNA1 GAr domain
Yeast-based models
Immune evasion
Doxorubicin
Daunorubicin
5-fluorouracil
Online Access:http://dmm.biologists.org/content/7/4/435

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