Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism

Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism

Tight control of storage and synthesis of glucose during nutritional transitions is essential to maintain blood glucose levels, a process in which the liver has a central role. PPAR𝛼 is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPAR𝛼 in balancing...

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Main Authors: Annelies Peeters, Myriam Baes
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2010/572405
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spelling doaj-f6b5345cf3cc4aff87f98c92b00644fb2020-11-24T21:05:35ZengHindawi LimitedPPAR Research1687-47571687-47652010-01-01201010.1155/2010/572405572405Role of PPAR𝛼 in Hepatic Carbohydrate MetabolismAnnelies Peeters0Myriam Baes1Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, K.U.Leuven, Campus Gasthuisberg O/N2, 3000 Leuven, BelgiumLaboratory of Cell Metabolism, Department of Pharmaceutical Sciences, K.U.Leuven, Campus Gasthuisberg O/N2, 3000 Leuven, BelgiumTight control of storage and synthesis of glucose during nutritional transitions is essential to maintain blood glucose levels, a process in which the liver has a central role. PPAR𝛼 is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPAR𝛼 in balancing glucose homeostasis as well. By using PPAR𝛼 ligands and PPAR𝛼−/− mice, several crucial genes were shown to be regulated by PPAR𝛼 in a direct or indirect way. We here review recent evidence that PPAR𝛼 contributes to the adaptation of hepatic carbohydrate metabolism during the fed-to-fasted or fasted-to-fed transition in rodents.http://dx.doi.org/10.1155/2010/572405
collection DOAJ
language English
format Article
sources DOAJ
author Annelies Peeters
Myriam Baes
spellingShingle Annelies Peeters
Myriam Baes
Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism
PPAR Research
author_facet Annelies Peeters
Myriam Baes
author_sort Annelies Peeters
title Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism
title_short Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism
title_full Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism
title_fullStr Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism
title_full_unstemmed Role of PPAR𝛼 in Hepatic Carbohydrate Metabolism
title_sort role of ppar𝛼 in hepatic carbohydrate metabolism
publisher Hindawi Limited
series PPAR Research
issn 1687-4757
1687-4765
publishDate 2010-01-01
description Tight control of storage and synthesis of glucose during nutritional transitions is essential to maintain blood glucose levels, a process in which the liver has a central role. PPAR𝛼 is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPAR𝛼 in balancing glucose homeostasis as well. By using PPAR𝛼 ligands and PPAR𝛼−/− mice, several crucial genes were shown to be regulated by PPAR𝛼 in a direct or indirect way. We here review recent evidence that PPAR𝛼 contributes to the adaptation of hepatic carbohydrate metabolism during the fed-to-fasted or fasted-to-fed transition in rodents.
url http://dx.doi.org/10.1155/2010/572405
work_keys_str_mv AT anneliespeeters roleofpparαinhepaticcarbohydratemetabolism
AT myriambaes roleofpparαinhepaticcarbohydratemetabolism
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