Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice

Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice

Nicotine administration enhances object recognition memory. However, target brain regions and cellular mechanisms underlying the nicotine effects remain unclear. In mice, the novel object recognition test revealed that systemic nicotine administration before training enhanced object recognition memo...

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Main Authors: Hirohito Esaki, Shoma Izumi, Akari Fukao, Naoya Nishitani, Satoshi Deyama, Katsuyuki Kaneda
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Journal of Pharmacological Sciences
Subjects:
Nicotine
Medial prefrontal cortex
Voltage-dependent potassium 7 channels
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861321000517
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spelling doaj-f6b96e5203f94a01b41c77d63450a9d62021-07-21T04:10:33ZengElsevierJournal of Pharmacological Sciences1347-86132021-09-0114715861Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of miceHirohito Esaki0Shoma Izumi1Akari Fukao2Naoya Nishitani3Satoshi Deyama4Katsuyuki Kaneda5Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa 920-1192, JapanLaboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa 920-1192, JapanLaboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa 920-1192, JapanLaboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa 920-1192, JapanLaboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa 920-1192, JapanCorresponding author.; Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa 920-1192, JapanNicotine administration enhances object recognition memory. However, target brain regions and cellular mechanisms underlying the nicotine effects remain unclear. In mice, the novel object recognition test revealed that systemic nicotine administration before training enhanced object recognition memory. Moreover, this effect was inhibited by infusion of retigabine, a selective voltage-dependent potassium 7 (Kv7) channel opener, into the medial prefrontal cortex (mPFC) before nicotine administration. Additionally, infusion of XE-991, a selective Kv7 channel blocker, into the mPFC before training enhanced object recognition memory. Therefore, Kv7 channels in the mPFC may be at least partly involved in nicotine-induced enhancement of object recognition memory.http://www.sciencedirect.com/science/article/pii/S1347861321000517NicotineMedial prefrontal cortexVoltage-dependent potassium 7 channels
collection DOAJ
language English
format Article
sources DOAJ
author Hirohito Esaki
Shoma Izumi
Akari Fukao
Naoya Nishitani
Satoshi Deyama
Katsuyuki Kaneda
spellingShingle Hirohito Esaki
Shoma Izumi
Akari Fukao
Naoya Nishitani
Satoshi Deyama
Katsuyuki Kaneda
Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice
Journal of Pharmacological Sciences
Nicotine
Medial prefrontal cortex
Voltage-dependent potassium 7 channels
author_facet Hirohito Esaki
Shoma Izumi
Akari Fukao
Naoya Nishitani
Satoshi Deyama
Katsuyuki Kaneda
author_sort Hirohito Esaki
title Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice
title_short Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice
title_full Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice
title_fullStr Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice
title_full_unstemmed Nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice
title_sort nicotine enhances object recognition memory through inhibition of voltage-dependent potassium 7 channels in the medial prefrontal cortex of mice
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2021-09-01
description Nicotine administration enhances object recognition memory. However, target brain regions and cellular mechanisms underlying the nicotine effects remain unclear. In mice, the novel object recognition test revealed that systemic nicotine administration before training enhanced object recognition memory. Moreover, this effect was inhibited by infusion of retigabine, a selective voltage-dependent potassium 7 (Kv7) channel opener, into the medial prefrontal cortex (mPFC) before nicotine administration. Additionally, infusion of XE-991, a selective Kv7 channel blocker, into the mPFC before training enhanced object recognition memory. Therefore, Kv7 channels in the mPFC may be at least partly involved in nicotine-induced enhancement of object recognition memory.
topic Nicotine
Medial prefrontal cortex
Voltage-dependent potassium 7 channels
url http://www.sciencedirect.com/science/article/pii/S1347861321000517
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AT satoshideyama nicotineenhancesobjectrecognitionmemorythroughinhibitionofvoltagedependentpotassium7channelsinthemedialprefrontalcortexofmice
AT katsuyukikaneda nicotineenhancesobjectrecognitionmemorythroughinhibitionofvoltagedependentpotassium7channelsinthemedialprefrontalcortexofmice
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