Akt Inhibitor A-443654 Interferes with Mitotic Progression by Regulating Aurora A Kinase Expression
Both Akt and Aurora A kinase have been shown to be important targets for intervention for cancer therapy. We report here that Compound A (A-443654), a specific Akt inhibitor, interferes with mitotic progression and bipolar spindle formation. Compound A induces G2/M accumulation, defects in centroso...
Main Authors: | Xuesong Liu, Yan Shi, Keith W. Woods, Paul Hessler, Paul Kroeger, Julie Wilsbacher, Jieyi Wang, Jean Y. Wang, Chunying Li, Qun Li, Saul H. Rosenberg, Vincent L. Giranda, Yan Luo |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2008-08-01
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Series: | Neoplasia: An International Journal for Oncology Research |
Online Access: | http://www.sciencedirect.com/science/article/pii/S147655860880036X |
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