Role of extracellular vesicles and microRNAs on dysfunctional angiogenesis during preeclamptic pregnancies
Preeclampsia is a syndrome characterized by hypertension during pregnancy, which is a leading cause of morbidity and mortality in both mother and newborn in developing countries. Some advances have increased the understanding of pathophysiology of this disease. For example, reduced utero-placental b...
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doaj-f6cf597e40834538b74cb8d08cda1bc82020-11-25T00:04:02ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2016-03-01710.3389/fphys.2016.00098181601Role of extracellular vesicles and microRNAs on dysfunctional angiogenesis during preeclamptic pregnanciesCarlos Alonso Escudero0Kurt eHerlitz1Felipe eTroncoso2Jesenia eAcurio3Claudio Aguayo Tapia4James eRoberts5Grace eTruong6Gregory eDuncombe7Gregory eRice8Gregory eRice9Carlos eSalomon10Carlos eSalomon11Universidad del Bio BioUniversidad del Bio BioUniversidad del Bio BioUniversidad del Bio BioUniversity of ConcepciónMagee-Womens Research Institute, University of Pittsburgh, USAThe University of QueenslandThe University of QueenslandThe University of QueenslandOchsner Clinic FoundationThe University of QueenslandOchsner Clinic FoundationPreeclampsia is a syndrome characterized by hypertension during pregnancy, which is a leading cause of morbidity and mortality in both mother and newborn in developing countries. Some advances have increased the understanding of pathophysiology of this disease. For example, reduced utero-placental blood flow associated with impaired trophoblast invasion may lead to a hypoxic placenta that releases harmful materials into the maternal and feto-placental circulation and impairs endothelial function. Identification of these harmful materials is one of the hot topics in the literature, since these provide potential biomarkers. Certainty, such knowledge will help us to understand the miscommunication between mother and fetus. In this review we highlight how placental extracellular vesicles and their cargo, such as small RNAs (i.e. microRNAs), might be involved in endothelial dysfunction during preeclampsia. Currently only a few reports have addressed the potential role of endothelial regulatory miRNA in preeclampsia. One of the main limitations in this area is the variability of the analyses performed in the current literature. This includes variability in the size of the particles analyzed, and broad variation in the exosomes considered. The quantity of microRNA targets genes suggest that practically all endothelial cell metabolic functions might be impaired. More studies are required to investigate mechanisms underlying miRNA released from placenta upon endothelial function.http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00098/fullExosomesMicroRNAshypothesisendothelial dysfunctionpathophysiologyPreeclampsia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carlos Alonso Escudero Kurt eHerlitz Felipe eTroncoso Jesenia eAcurio Claudio Aguayo Tapia James eRoberts Grace eTruong Gregory eDuncombe Gregory eRice Gregory eRice Carlos eSalomon Carlos eSalomon |
spellingShingle |
Carlos Alonso Escudero Kurt eHerlitz Felipe eTroncoso Jesenia eAcurio Claudio Aguayo Tapia James eRoberts Grace eTruong Gregory eDuncombe Gregory eRice Gregory eRice Carlos eSalomon Carlos eSalomon Role of extracellular vesicles and microRNAs on dysfunctional angiogenesis during preeclamptic pregnancies Frontiers in Physiology Exosomes MicroRNAs hypothesis endothelial dysfunction pathophysiology Preeclampsia |
author_facet |
Carlos Alonso Escudero Kurt eHerlitz Felipe eTroncoso Jesenia eAcurio Claudio Aguayo Tapia James eRoberts Grace eTruong Gregory eDuncombe Gregory eRice Gregory eRice Carlos eSalomon Carlos eSalomon |
author_sort |
Carlos Alonso Escudero |
title |
Role of extracellular vesicles and microRNAs on dysfunctional angiogenesis during preeclamptic pregnancies |
title_short |
Role of extracellular vesicles and microRNAs on dysfunctional angiogenesis during preeclamptic pregnancies |
title_full |
Role of extracellular vesicles and microRNAs on dysfunctional angiogenesis during preeclamptic pregnancies |
title_fullStr |
Role of extracellular vesicles and microRNAs on dysfunctional angiogenesis during preeclamptic pregnancies |
title_full_unstemmed |
Role of extracellular vesicles and microRNAs on dysfunctional angiogenesis during preeclamptic pregnancies |
title_sort |
role of extracellular vesicles and micrornas on dysfunctional angiogenesis during preeclamptic pregnancies |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2016-03-01 |
description |
Preeclampsia is a syndrome characterized by hypertension during pregnancy, which is a leading cause of morbidity and mortality in both mother and newborn in developing countries. Some advances have increased the understanding of pathophysiology of this disease. For example, reduced utero-placental blood flow associated with impaired trophoblast invasion may lead to a hypoxic placenta that releases harmful materials into the maternal and feto-placental circulation and impairs endothelial function. Identification of these harmful materials is one of the hot topics in the literature, since these provide potential biomarkers. Certainty, such knowledge will help us to understand the miscommunication between mother and fetus. In this review we highlight how placental extracellular vesicles and their cargo, such as small RNAs (i.e. microRNAs), might be involved in endothelial dysfunction during preeclampsia. Currently only a few reports have addressed the potential role of endothelial regulatory miRNA in preeclampsia. One of the main limitations in this area is the variability of the analyses performed in the current literature. This includes variability in the size of the particles analyzed, and broad variation in the exosomes considered. The quantity of microRNA targets genes suggest that practically all endothelial cell metabolic functions might be impaired. More studies are required to investigate mechanisms underlying miRNA released from placenta upon endothelial function. |
topic |
Exosomes MicroRNAs hypothesis endothelial dysfunction pathophysiology Preeclampsia |
url |
http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00098/full |
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