A Case of Hypogonadotropic Hypogonadism Caused by Opioid Treatment for Nonmalignant Chronic Pain

A Case of Hypogonadotropic Hypogonadism Caused by Opioid Treatment for Nonmalignant Chronic Pain

We report a case of 42-year-old male patient with hypogonadotropic hypogonadism. He suffered from general fatigue and erectile dysfunction after the treatment with transdermal fentanyl for chronic pain by traffic injury. Endocrine examinations and hormone stimulating tests showed that he had hypogon...

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Main Authors: Yukiko Tabuchi, Tetsuyuki Yasuda, Hideaki Kaneto, Tetsuhiro Kitamura, Junji Kozawa, Michio Otsuki, Akihisa Imagawa, Aya Nakae, Youichi Matsuda, Hironobu Uematsu, Takashi Mashimo, Masahiko Shibata, Iichiro Shimomura
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/2012/740603
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spelling doaj-f6cf654fa4f448bfb8b5e88c3618c8862020-11-24T20:52:57ZengHindawi LimitedCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/740603740603A Case of Hypogonadotropic Hypogonadism Caused by Opioid Treatment for Nonmalignant Chronic PainYukiko Tabuchi0Tetsuyuki Yasuda1Hideaki Kaneto2Tetsuhiro Kitamura3Junji Kozawa4Michio Otsuki5Akihisa Imagawa6Aya Nakae7Youichi Matsuda8Hironobu Uematsu9Takashi Mashimo10Masahiko Shibata11Iichiro Shimomura12Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanAnesthesiology and Intensive Care, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanAnesthesiology and Intensive Care, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Anesthesiology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Habikino 583-8588, JapanAnesthesiology and Intensive Care, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanPain Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, JapanWe report a case of 42-year-old male patient with hypogonadotropic hypogonadism. He suffered from general fatigue and erectile dysfunction after the treatment with transdermal fentanyl for chronic pain by traffic injury. Endocrine examinations and hormone stimulating tests showed that he had hypogonadotropic hypogonadism. Brain magnetic resonance imaging (MRI) showed no abnormal findings, and he had no past history of accounting for acquired hypogonadotropic hypogonadism. Therefore, his hypogonadism was diagnosed to be caused by opioid treatment. Although opioid-induced endocrine dysfunctions are not widely recognized, this case suggests that we should consider the possibility of endocrine dysfunctions in patients with opioid treatment.http://dx.doi.org/10.1155/2012/740603
collection DOAJ
language English
format Article
sources DOAJ
author Yukiko Tabuchi
Tetsuyuki Yasuda
Hideaki Kaneto
Tetsuhiro Kitamura
Junji Kozawa
Michio Otsuki
Akihisa Imagawa
Aya Nakae
Youichi Matsuda
Hironobu Uematsu
Takashi Mashimo
Masahiko Shibata
Iichiro Shimomura
spellingShingle Yukiko Tabuchi
Tetsuyuki Yasuda
Hideaki Kaneto
Tetsuhiro Kitamura
Junji Kozawa
Michio Otsuki
Akihisa Imagawa
Aya Nakae
Youichi Matsuda
Hironobu Uematsu
Takashi Mashimo
Masahiko Shibata
Iichiro Shimomura
A Case of Hypogonadotropic Hypogonadism Caused by Opioid Treatment for Nonmalignant Chronic Pain
Case Reports in Medicine
author_facet Yukiko Tabuchi
Tetsuyuki Yasuda
Hideaki Kaneto
Tetsuhiro Kitamura
Junji Kozawa
Michio Otsuki
Akihisa Imagawa
Aya Nakae
Youichi Matsuda
Hironobu Uematsu
Takashi Mashimo
Masahiko Shibata
Iichiro Shimomura
author_sort Yukiko Tabuchi
title A Case of Hypogonadotropic Hypogonadism Caused by Opioid Treatment for Nonmalignant Chronic Pain
title_short A Case of Hypogonadotropic Hypogonadism Caused by Opioid Treatment for Nonmalignant Chronic Pain
title_full A Case of Hypogonadotropic Hypogonadism Caused by Opioid Treatment for Nonmalignant Chronic Pain
title_fullStr A Case of Hypogonadotropic Hypogonadism Caused by Opioid Treatment for Nonmalignant Chronic Pain
title_full_unstemmed A Case of Hypogonadotropic Hypogonadism Caused by Opioid Treatment for Nonmalignant Chronic Pain
title_sort case of hypogonadotropic hypogonadism caused by opioid treatment for nonmalignant chronic pain
publisher Hindawi Limited
series Case Reports in Medicine
issn 1687-9627
1687-9635
publishDate 2012-01-01
description We report a case of 42-year-old male patient with hypogonadotropic hypogonadism. He suffered from general fatigue and erectile dysfunction after the treatment with transdermal fentanyl for chronic pain by traffic injury. Endocrine examinations and hormone stimulating tests showed that he had hypogonadotropic hypogonadism. Brain magnetic resonance imaging (MRI) showed no abnormal findings, and he had no past history of accounting for acquired hypogonadotropic hypogonadism. Therefore, his hypogonadism was diagnosed to be caused by opioid treatment. Although opioid-induced endocrine dysfunctions are not widely recognized, this case suggests that we should consider the possibility of endocrine dysfunctions in patients with opioid treatment.
url http://dx.doi.org/10.1155/2012/740603
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