Cases of severe Clostridium difficile colitis proceeding with symptoms of peritonitis
Recently there was an increase of Clostridium difficile infection cases with the development of severe pseudomembranous colitis with high mortality and high percentage of backsets. Major reason for this growing problem is the emergence of newer, more virulent and more antibiotic-resistant strains in...
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Scientific Сentre for Family Health and Human Reproduction Problems
2015-07-01
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doaj-f6dbff00d68e4f668f37bcfd9bed0a702021-08-17T13:52:52ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962015-07-010471182Cases of severe Clostridium difficile colitis proceeding with symptoms of peritonitisE. I. Belinskaya0Irkutsk Municipal Clinical Hospital N 1; Irkutsk State Medical University; Russia Saint Petersburg State UniversityRecently there was an increase of Clostridium difficile infection cases with the development of severe pseudomembranous colitis with high mortality and high percentage of backsets. Major reason for this growing problem is the emergence of newer, more virulent and more antibiotic-resistant strains including PCR ribotype 027. The major risk factors for pseudomembranous colitis are hospitalizing, antibiotics exposure, chemotherapy, use of proton-pumps inhibitors, older age, concomitant diseases. The appearance of diarrhea, acute abdominal pain, leukocytosis, hypoproteinemia after antibiotic therapy should be considered as a basis for targeted diagnostics of pseudomembranous colitis with the use of laboratory tests. Fulminant pseudomembranous colitis occurs in 5 % of patient with Clostridium difficile infection. This patients often have severe abdominal pain and can have signs of peritonitis and a markedly increased white blood cells. Colectomy should be considered in patients with fulminant colitis. The mortality rate in fulminant pseudomembranous colitis is up to 70 %. The basis for the prevention of pseudomembranous colitis is a rational prescription of antibacterial agents.https://www.actabiomedica.ru/jour/article/view/82pseudomembranous colitisclostridium difficile infectionperitonitis |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
E. I. Belinskaya |
spellingShingle |
E. I. Belinskaya Cases of severe Clostridium difficile colitis proceeding with symptoms of peritonitis Acta Biomedica Scientifica pseudomembranous colitis clostridium difficile infection peritonitis |
author_facet |
E. I. Belinskaya |
author_sort |
E. I. Belinskaya |
title |
Cases of severe Clostridium difficile colitis proceeding with symptoms of peritonitis |
title_short |
Cases of severe Clostridium difficile colitis proceeding with symptoms of peritonitis |
title_full |
Cases of severe Clostridium difficile colitis proceeding with symptoms of peritonitis |
title_fullStr |
Cases of severe Clostridium difficile colitis proceeding with symptoms of peritonitis |
title_full_unstemmed |
Cases of severe Clostridium difficile colitis proceeding with symptoms of peritonitis |
title_sort |
cases of severe clostridium difficile colitis proceeding with symptoms of peritonitis |
publisher |
Scientific Сentre for Family Health and Human Reproduction Problems |
series |
Acta Biomedica Scientifica |
issn |
2541-9420 2587-9596 |
publishDate |
2015-07-01 |
description |
Recently there was an increase of Clostridium difficile infection cases with the development of severe pseudomembranous colitis with high mortality and high percentage of backsets. Major reason for this growing problem is the emergence of newer, more virulent and more antibiotic-resistant strains including PCR ribotype 027. The major risk factors for pseudomembranous colitis are hospitalizing, antibiotics exposure, chemotherapy, use of proton-pumps inhibitors, older age, concomitant diseases. The appearance of diarrhea, acute abdominal pain, leukocytosis, hypoproteinemia after antibiotic therapy should be considered as a basis for targeted diagnostics of pseudomembranous colitis with the use of laboratory tests. Fulminant pseudomembranous colitis occurs in 5 % of patient with Clostridium difficile infection. This patients often have severe abdominal pain and can have signs of peritonitis and a markedly increased white blood cells. Colectomy should be considered in patients with fulminant colitis. The mortality rate in fulminant pseudomembranous colitis is up to 70 %. The basis for the prevention of pseudomembranous colitis is a rational prescription of antibacterial agents. |
topic |
pseudomembranous colitis clostridium difficile infection peritonitis |
url |
https://www.actabiomedica.ru/jour/article/view/82 |
work_keys_str_mv |
AT eibelinskaya casesofsevereclostridiumdifficilecolitisproceedingwithsymptomsofperitonitis |
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