Drug-Induced Nephrotoxicity and Dose Adjustment Recommendations: Agreement Among Four Drug Information Sources
: Hospitalized patients require the use of a variety of drugs, many of which individually or in combination have the potential to cause kidney damage. The use of potentially nephrotoxic drugs is often unavoidable, and the need for dose adjustment should be evaluated. This study is aimed at assessing...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2015-09-01
|
Series: | International Journal of Environmental Research and Public Health |
Subjects: | |
Online Access: | http://www.mdpi.com/1660-4601/12/9/11227 |
id |
doaj-f6dcde7109904c3f8762048d203a292e |
---|---|
record_format |
Article |
spelling |
doaj-f6dcde7109904c3f8762048d203a292e2020-11-25T02:32:43ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012015-09-01129112271124010.3390/ijerph120911227ijerph120911227Drug-Induced Nephrotoxicity and Dose Adjustment Recommendations: Agreement Among Four Drug Information SourcesMillena Drumond Bicalho0Danielly Botelho Soares1Fernando Antonio Botoni2Adriano Max Moreira Reis3Maria Auxiliadora Parreiras Martins4Maternidade Hospital Octaviano Neves, Rua Ceará, 186, Bairro Santa Efigênia, Belo Horizonte CEP 30150-310, MG, BrazilFaculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Campus Pampulha, Belo Horizonte, CEP 31270-901, MG, BrazilFaculdade de Medicina, Universidade Federal de Minas Gerais, Av. Alfredo Balena, 190, Belo Horizonte, CEP 30130-100, MG, BrazilFaculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Campus Pampulha, Belo Horizonte, CEP 31270-901, MG, BrazilFaculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Campus Pampulha, Belo Horizonte, CEP 31270-901, MG, Brazil: Hospitalized patients require the use of a variety of drugs, many of which individually or in combination have the potential to cause kidney damage. The use of potentially nephrotoxic drugs is often unavoidable, and the need for dose adjustment should be evaluated. This study is aimed at assessing concordance in information on drug-induced nephrotoxicity and dose adjustment recommendations by comparing four drug information sources (DRUGDEX®, UpToDate®, Medscape® and the Brazilian Therapeutic Formulary) using the formulary of a Brazilian public hospital. A total of 218 drugs were investigated. The global Fleiss’ kappa coefficient was 0.265 for nephrotoxicity (p < 0.001; CI 95%, 0.211–0.319) and 0.346 for recommendations (p < 0.001; CI 95%, 0.292–0.401), indicating fair concordance among the sources. Anti-infectives and anti-hypertensives were the main drugs cited as nephrotoxic by the different sources. There were no clear definitions for qualitative data or quantitative values for dose adjustments among the four information sources. There was no advice for dosing for a large number of the drugs in the international databases. The National Therapeutic Formulary offered imprecise dose adjustment recommendations for many nephrotoxic drugs. Discrepancies among information sources may have a clinical impact on patient care and contribute to drug-related morbidity and mortality.http://www.mdpi.com/1660-4601/12/9/11227kidney insufficiencydrug toxicitydrug information |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Millena Drumond Bicalho Danielly Botelho Soares Fernando Antonio Botoni Adriano Max Moreira Reis Maria Auxiliadora Parreiras Martins |
spellingShingle |
Millena Drumond Bicalho Danielly Botelho Soares Fernando Antonio Botoni Adriano Max Moreira Reis Maria Auxiliadora Parreiras Martins Drug-Induced Nephrotoxicity and Dose Adjustment Recommendations: Agreement Among Four Drug Information Sources International Journal of Environmental Research and Public Health kidney insufficiency drug toxicity drug information |
author_facet |
Millena Drumond Bicalho Danielly Botelho Soares Fernando Antonio Botoni Adriano Max Moreira Reis Maria Auxiliadora Parreiras Martins |
author_sort |
Millena Drumond Bicalho |
title |
Drug-Induced Nephrotoxicity and Dose Adjustment Recommendations: Agreement Among Four Drug Information Sources |
title_short |
Drug-Induced Nephrotoxicity and Dose Adjustment Recommendations: Agreement Among Four Drug Information Sources |
title_full |
Drug-Induced Nephrotoxicity and Dose Adjustment Recommendations: Agreement Among Four Drug Information Sources |
title_fullStr |
Drug-Induced Nephrotoxicity and Dose Adjustment Recommendations: Agreement Among Four Drug Information Sources |
title_full_unstemmed |
Drug-Induced Nephrotoxicity and Dose Adjustment Recommendations: Agreement Among Four Drug Information Sources |
title_sort |
drug-induced nephrotoxicity and dose adjustment recommendations: agreement among four drug information sources |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1660-4601 |
publishDate |
2015-09-01 |
description |
: Hospitalized patients require the use of a variety of drugs, many of which individually or in combination have the potential to cause kidney damage. The use of potentially nephrotoxic drugs is often unavoidable, and the need for dose adjustment should be evaluated. This study is aimed at assessing concordance in information on drug-induced nephrotoxicity and dose adjustment recommendations by comparing four drug information sources (DRUGDEX®, UpToDate®, Medscape® and the Brazilian Therapeutic Formulary) using the formulary of a Brazilian public hospital. A total of 218 drugs were investigated. The global Fleiss’ kappa coefficient was 0.265 for nephrotoxicity (p < 0.001; CI 95%, 0.211–0.319) and 0.346 for recommendations (p < 0.001; CI 95%, 0.292–0.401), indicating fair concordance among the sources. Anti-infectives and anti-hypertensives were the main drugs cited as nephrotoxic by the different sources. There were no clear definitions for qualitative data or quantitative values for dose adjustments among the four information sources. There was no advice for dosing for a large number of the drugs in the international databases. The National Therapeutic Formulary offered imprecise dose adjustment recommendations for many nephrotoxic drugs. Discrepancies among information sources may have a clinical impact on patient care and contribute to drug-related morbidity and mortality. |
topic |
kidney insufficiency drug toxicity drug information |
url |
http://www.mdpi.com/1660-4601/12/9/11227 |
work_keys_str_mv |
AT millenadrumondbicalho druginducednephrotoxicityanddoseadjustmentrecommendationsagreementamongfourdruginformationsources AT daniellybotelhosoares druginducednephrotoxicityanddoseadjustmentrecommendationsagreementamongfourdruginformationsources AT fernandoantoniobotoni druginducednephrotoxicityanddoseadjustmentrecommendationsagreementamongfourdruginformationsources AT adrianomaxmoreirareis druginducednephrotoxicityanddoseadjustmentrecommendationsagreementamongfourdruginformationsources AT mariaauxiliadoraparreirasmartins druginducednephrotoxicityanddoseadjustmentrecommendationsagreementamongfourdruginformationsources |
_version_ |
1724818309004656640 |