Pellucidin A promotes antinociceptive activity by peripheral mechanisms inhibiting COX-2 and NOS: In vivo and in silico study.

Peperomia pellucida (PP) belongs to the Peperomia genus, which has a pantropic distribution. PP is used to treat a wide range of symptoms and diseases, such as pain, inflammation, and hypertension. Intriguingly, PP extract is used by different tropical countries for its anti-inflammatory and antinoc...

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Main Authors:	Amanda Pâmela Santos Queiroz, Manolo Cleiton Costa Freitas, José Rogério A Silva, Anderson Bentes Lima, Leila Sawada, Rayan Fidel Martins Monteiro, Ana Carolina Gomes Albuquerque de Freitas, Luís Antônio Loureiro Maués, Alberto Cardoso Arruda, Milton Nascimento Silva, Cristiane Socorro Ferraz Maia, Enéas Andrade Fontes-Júnior, José Luiz M do Nascimento, Mara Silvia P Arruda, Gilmara N T Bastos
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2020-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0238834

Pellucidin A promotes antinociceptive activity by peripheral mechanisms inhibiting COX-2 and NOS: In vivo and in silico study

by Amanda Pâmela Santos Queiroz, Manolo Cleiton Costa Freitas, José Rogério A. Silva, Anderson Bentes Lima, Leila Sawada, Rayan Fidel Martins Monteiro, Ana Carolina Gomes Albuquerque de Freitas, Luís Antônio Loureiro Maués, Alberto Cardoso Arruda, Milton Nascimento Silva, Cristiane Socorro Ferraz Maia, Enéas Andrade Fontes-Júnior, José Luiz M. do Nascimento, Mara Silvia P. Arruda, Gilmara N. T. Bastos, John M. Streicher
Published 2020-01-01

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Pellucidin A promotes antinociceptive activity by peripheral mechanisms inhibiting COX-2 and NOS: In vivo and in silico study.

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