HA-1H T-Cell Receptor Gene Transfer to Redirect Virus-Specific T Cells for Treatment of Hematological Malignancies After Allogeneic Stem Cell Transplantation: A Phase 1 Clinical Study

HA-1H T-Cell Receptor Gene Transfer to Redirect Virus-Specific T Cells for Treatment of Hematological Malignancies After Allogeneic Stem Cell Transplantation: A Phase 1 Clinical Study

Graft-vs.-leukemia (GVL) reactivity after HLA-matched allogeneic stem cell transplantation (alloSCT) is mainly mediated by donor T cells recognizing minor histocompatibility antigens (MiHA). If MiHA are targeted that are exclusively expressed on hematopoietic cells of recipient origin, selective GVL...

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Bibliographic Details
Main Authors: Peter van Balen, Inge Jedema, Marleen M. van Loenen, Renate de Boer, H. M. van Egmond, Renate S. Hagedoorn, Conny Hoogstaten, Sabrina A. J. Veld, Lois Hageman, P. A. G. van Liempt, Jaap-Jan Zwaginga, Pauline Meij, H. Veelken, J. H. F. Falkenburg, Mirjam H. M. Heemskerk
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
HA-1
TCR gene transfer
minor histocompatibility antigen
allogeneic stem cell transplantation
graft-vs.-tumor effect
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01804/full

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